Milk Precipitins, Circulating Immune Complexes and IgA Deficiency

  • Charlotte Cunningham-Rundles
  • Werner E. Brandeis
  • Robert A. Good
  • Noorbibi K. Day
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)


It has been known for some years that the gastrointestinal tract of the newborn is permeable to macromolecules, and that undigested food antigens such as cow’s milk can enter the circulation and stimulate the production of antibodies (1–3). Many normal infants up to the age of 3 months develop precipitating antibodies after the introduction of cow’s milk into the diet but these antibodies disappear with age and are ultimately found in only 1–2% of the general population (3,4). However, in one immunodeficiency disease, selective IgA deficiency, milk precipitins are commonly found in all age groups (4).


Immune Complex Milk Protein Rectal Prolapse Common Variable Immunodeficiency Food Antigen 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Charlotte Cunningham-Rundles
    • 1
  • Werner E. Brandeis
    • 1
  • Robert A. Good
    • 1
  • Noorbibi K. Day
    • 1
  1. 1.Memorial Sloan-Kettering Cancer CenterNew YorkUSA

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