Serologic and Structural Comparisons of Rabbit IgA Allotypes

  • Kathrine L. Knight
  • Bernard Friedenson
  • W. Carey Hanly
  • Thomas R. Malek
  • Bruce E. Peterson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)


Two subclasses of rabbit IgA, IgA-f and IgA-g, have been identified (1,2) and genetic variants of each subclass have been found (1–4). These genetic variants, identified immunologically, are designated allotypes. The IgA-f allotypic specificities, f69, f70, f71, f72 and f73, are controlled by allelic genes f 69, f 70, f 71, f 72, and f 73, respectively at the f locus and the IgA-g allotypic specificities, g74, g75, g76, and g77 are controlled by allelic genes g 74, g 75, g 76, and g 77, respectively, at the g locus. The f and g loci are closely linked to each other and to the chromosomal region controlling the synthesis of the variable (V) and constant (C) regions of immunoglobulin (Ig) heavy chains (5).


Disulfide Bond Amino Acid Difference Alpha Chain Allelic Gene Multiple Determinant 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Kathrine L. Knight
  • Bernard Friedenson
    • 1
  • W. Carey Hanly
    • 1
  • Thomas R. Malek
    • 1
  • Bruce E. Peterson
    • 1
  1. 1.Departments of Microbiology, Biochemistry, and Preventive Medicine and Community HealthUniversity of Illinois at the Medical CenterChicagoUSA

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