Advertisement

Serologic and Structural Comparisons of Rabbit IgA Allotypes

  • Kathrine L. Knight
  • Bernard Friedenson
  • W. Carey Hanly
  • Thomas R. Malek
  • Bruce E. Peterson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)

Abstract

Two subclasses of rabbit IgA, IgA-f and IgA-g, have been identified (1,2) and genetic variants of each subclass have been found (1–4). These genetic variants, identified immunologically, are designated allotypes. The IgA-f allotypic specificities, f69, f70, f71, f72 and f73, are controlled by allelic genes f 69, f 70, f 71, f 72, and f 73, respectively at the f locus and the IgA-g allotypic specificities, g74, g75, g76, and g77 are controlled by allelic genes g 74, g 75, g 76, and g 77, respectively, at the g locus. The f and g loci are closely linked to each other and to the chromosomal region controlling the synthesis of the variable (V) and constant (C) regions of immunoglobulin (Ig) heavy chains (5).

Keywords

Disulfide Bond Amino Acid Difference Alpha Chain Allelic Gene Multiple Determinant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Conway, T. P., Dray, S. and Lichter, E. A., J. Immunol. 102: 544, 1969.PubMedGoogle Scholar
  2. 2.
    Conway, T. P., Dray, S. and Lichter, E. A., J. Immunol. 103: 662, 1969.PubMedGoogle Scholar
  3. 3.
    Lammert, J. M., Dray, S., Knight, K. L. and Hanly, W. C., J. Immunol. 118: 1397, 1977.PubMedGoogle Scholar
  4. 4.
    Knight, K. L. and Hanly, W. C., in Contemporary Topics in Molecular Immunology (Edited by Inman, F. P. and Mandy, W. J.) Vol. 4, p. 55, Plenum Publishing Corp., New York, 1975.Google Scholar
  5. 5.
    Hanly, W. C., Knight, K. L., Gilman-Sachs, A., Dray, S. and Lichter, E. A., J. Immunol. 108: 1723, 1972.PubMedGoogle Scholar
  6. 6.
    Knight, K. L., Lichter, E. A. and Hanly, W. C., Biochemistry 12: 3197, 1973.PubMedCrossRefGoogle Scholar
  7. 7.
    Malek, T. R., Hanly, W. C. and Knight, K. L., Eur. J. Immunol. 4: 692, 1974.PubMedCrossRefGoogle Scholar
  8. 8.
    Tseng, J. and Knight, K. L., J. Immunol. 115: 454, 1975.PubMedGoogle Scholar
  9. 9.
    Hanly, W. C., Lichter, E. A., Dray, S. and Knight, K. L., Biochemistry 12: 733, 1973.PubMedCrossRefGoogle Scholar
  10. 10.
    Cebra, J. J. and Robbins, J. B., J. Immunol. 97: 12, 1966.PubMedGoogle Scholar
  11. 11.
    MacFarlane, A. S., Nature 182: 53, 1958.Google Scholar
  12. 12.
    Friedenson, B. A., Takeda, Y., Roholt, O. and Pressman, D., Eur. J. Biochem. 27: 31, 1972.PubMedCrossRefGoogle Scholar
  13. 13.
    Williams, D. E. and Reisfeld, R. A., Ann. N.Y. Acad. Sci. 121: 373, 1964.PubMedCrossRefGoogle Scholar
  14. 14.
    Friedenson, B., Appella, E., Takeda, Y., Roholt, O. A. and Pressman, D., J. Biol. Chem. 248: 7073, 1973.PubMedGoogle Scholar
  15. 15.
    Axen, R., Porath, J. and Ernback, S., Nature 214: 1302, 1967.PubMedCrossRefGoogle Scholar
  16. 16.
    Wofsy, L. and Burr, B., J. Immunol. 103: 380, 1969.PubMedGoogle Scholar
  17. 17.
    Friedenson, B., Hora, J. and Wang, L. S., Biochemistry 15: 4876, 1976.PubMedCrossRefGoogle Scholar
  18. 18.
    Pisano, J. J. and Bronzert, T. J., J. Biol. Chem. 244: 5597, 1969.PubMedGoogle Scholar
  19. 19.
    Smithies, E., Gibson, D., Fanning, E. M., Goodfleisch, R. M., Gilman, J. G. and Ballantyne, D. L., Biochemistry 10: 4912, 1971.PubMedCrossRefGoogle Scholar
  20. 20.
    Lammert, J., Ph.D. Thesis, University of Illinois at the Medical Center, Chicago, Illinois.Google Scholar
  21. 21.
    Kratzin, H., Altevogt, P., Ruban, E., Kortt, A., Staroscik, K. and Hilschmann, N., Hoppe-Seyler’s 2. Physiol. Chem. 356: 1337, 1975.Google Scholar
  22. 22.
    Liu, Y. V., Low, T.L.K., Infante, I. and Putnam, F. W., Science 193: 1017, 1976.PubMedCrossRefGoogle Scholar
  23. 23.
    Torano, A., Tsuzukida, Y., Liu, Y. V. and Putnam, F. W., Pro. Natl. Acad. Sci. (USA) 74: 2301, 1977.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Kathrine L. Knight
  • Bernard Friedenson
    • 1
  • W. Carey Hanly
    • 1
  • Thomas R. Malek
    • 1
  • Bruce E. Peterson
    • 1
  1. 1.Departments of Microbiology, Biochemistry, and Preventive Medicine and Community HealthUniversity of Illinois at the Medical CenterChicagoUSA

Personalised recommendations