Studies on Oral Adjuvants Against Murine Salmonellosis
Besredka originally postulated the primary role of local immune mechanisms in protection against enteric bacterial infections over 40 years ago (1). Since then, there have been many studies pertaining to this subject (2,3) indicating importance of locally produced antibodies as a “first line of defense.” It is also clear that this local antibody is best elicited by local immunization. However, it has been noted that such local antibacterial protection is of short duration in the absence of further antigenic stimulus. This might indicate that repeated immunization is necessary, which may be difficult for mass application. Therefore, one of the approaches for developing effective prophylaxis against enteric diseases is to search for oral adjuvants which, when administered with the vaccine, will prolong and enhance vaccine-generated local immunities.
KeywordsEnteric Fever Colony Count None None Pertussis Vaccine Oral Challenge
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