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Studies on Oral Adjuvants Against Murine Salmonellosis

  • R. Ganguly
  • R. H. Waldman
  • R. D’Alessandri
  • G. Sutherland
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)

Abstract

Besredka originally postulated the primary role of local immune mechanisms in protection against enteric bacterial infections over 40 years ago (1). Since then, there have been many studies pertaining to this subject (2,3) indicating importance of locally produced antibodies as a “first line of defense.” It is also clear that this local antibody is best elicited by local immunization. However, it has been noted that such local antibacterial protection is of short duration in the absence of further antigenic stimulus. This might indicate that repeated immunization is necessary, which may be difficult for mass application. Therefore, one of the approaches for developing effective prophylaxis against enteric diseases is to search for oral adjuvants which, when administered with the vaccine, will prolong and enhance vaccine-generated local immunities.

Keywords

Enteric Fever Colony Count None None Pertussis Vaccine Oral Challenge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Besredka, A., The Williams & Wilkins Co., Baltimore, 1927.Google Scholar
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    Ganguly, R., Clem, L. W., Bencic, Z., Sinha, R., Sakazaki, R. and Waldman, R. H., Bull. Wld. Hlth. Org. 52: 323, 1975.Google Scholar
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    Ganguly, R., Ogra, P. L., Regas, J. and Waldman, R. H., Infect. Immun. 8: 497, 1973.PubMedGoogle Scholar
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    Kétyi, I. and Rauss, K., Acta. Microbiol. Acad. Sci. Hung. 14: 165, 1967.PubMedGoogle Scholar
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    Symoens, J. and Rosenthal, M., J. Reticuloendo. Soc. 21: 175, 1977.Google Scholar
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    Singhal, S. K., Naspitz, C. K. and Richter, M., Int. Arch. Allergy 31: 390, 1967.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • R. Ganguly
    • 1
    • 2
  • R. H. Waldman
    • 1
    • 2
  • R. D’Alessandri
    • 1
    • 2
  • G. Sutherland
    • 1
    • 2
  1. 1.Department of MedicineWest Virginia University Medical CenterMorgantownUSA
  2. 2.University of Florida College of MedicineGainesvilleUSA

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