Motility of the Pathogen and Intestinal Immunity of the Host in Experimental Cholera

  • Robert J. Yancey
  • L. Joe Berry
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)


Previous studies from our laboratory have shown that motility is an important virulence factor for V. cholerae. Guentzel and Berry (1) observed that fully toxigenic and prototrophic, non-motile mutants were less able to cause disease following oral challenge in suckling mice than wild type parental strains. Moreover, motile organisms penetrated in larger numbers into intervillous spaces and crypts of Lieberkuhn than did nonmotile strains (2). Nonmotile strains were also less virulent for adult mice infected intraperitoneally with the organisms suspended in hog gastric mucin than parental strains (3). In studies of isolated ileal loops of adult rabbits Williams et al. (4) observed that motile vibrios penetrated into the crypts of Lieberkuhn more readily than did nonmotile strains.


Wild Type Strain Adult Rabbit Ileal Loop Passive Protection Suckling Mouse 


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  1. 1.
    Guentzel, M. N. and Berry, L. J., Infect. Immun. 11: 890, 1975.PubMedGoogle Scholar
  2. 2.
    Guentzel, M. N., Field, L. H., Eubanks, E. R. and Berry, L. J., Infect. Immun. 15: 539, 1977.PubMedGoogle Scholar
  3. 3.
    Eubanks, E. R., Guentzel, M. N. and Berry, L. J., Infect. Immun. 13: 457, 1976.PubMedGoogle Scholar
  4. 4.
    Williams, H. R., Jr., Verwey, W. F., Schrank, G. D. and Hurry, E. K., in Symposium on Cholera, U.S.-Japan Cooperative Medical Science Program, p. 161, 1973.Google Scholar
  5. 5.
    Eubanks, E. R., Guentzel, M. N. and Berry, L. J., Infect. Immun. 15: 533, 1977.PubMedGoogle Scholar
  6. 6.
    De, S. N. and Chatterjee, D. N., J. Pathol. Bacteriol. 66: 153, 1953.CrossRefGoogle Scholar
  7. 7.
    Schrank, G. D., Stager, C. E. and Verwey, W. F., Infect. Immun. 7: 827, 1973.PubMedGoogle Scholar
  8. 8.
    White, C., Biometrics 8: 33, 1952.CrossRefGoogle Scholar
  9. 9.
    Fubara, E. S. and Freter, R., J. Immunol. 111: 395, 1973.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Robert J. Yancey
    • 1
  • L. Joe Berry
    • 1
  1. 1.Department of MicrobiologyThe University of Texas at AustinAustinUSA

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