The Role of Antigen form and the Induction of an Intestinal Immune Response to Cholera Toxin/Toxoid in Rats

  • Nathaniel F. Pierce
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)


Recent efforts to immunize against cholera have focused upon the protective role of antitoxin. We have studied the intestinal immune response to cholera toxin and toxoid in rats with two aims; first, to describe basic features of the secretory immune system of the gut using cholera toxin and toxoid as antigenic probes, and second, to provide an experimental basis for further efforts to induce antitoxic immunity in man.


Cholera Toxin Mucosal Immune Response Local Immune Response Antigen Form Booster Response 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Nathaniel F. Pierce
    • 1
  1. 1.Departments of MedicineBaltimore City Hospitals and Johns Hopkins University School of MedicineBaltimoreUSA

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