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Passive Immunization with Antisera to Streptococcus Mutans in the Prevention of Caries in Rhesus Monkeys

  • T. Lehner
  • M. W. Russell
  • J. M. A. Wilton
  • S. J. Challacombe
  • C. M. Scully
  • Jane E. Hawkes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)

Abstract

Immunization with Streptococcus mutans in rhesus monkeys elicits both antibodies and cell-mediated immunity (1). Serum IgG antibodies to S. mutans have been consistently associated with protection against caries. A significant correlation was found between skin delayed hypersensitivity (DH) or the lymphoproliferative response and IgG but not IgM antibodies to S. mutans. This raised the possibility that the cell-mediated immune responses might be a measure of T-cell helper function (2). Although direct evidence for T-cell helper function is not yet available, this is probable, as IgG antibodies are thymus-dependent to a much greater extent than the IgM antibodies (3).

Keywords

Dental Caries Transfer Factor Dental Plaque Carious Lesion Passive Immunization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • T. Lehner
    • 1
  • M. W. Russell
    • 1
  • J. M. A. Wilton
    • 1
  • S. J. Challacombe
    • 1
  • C. M. Scully
    • 1
  • Jane E. Hawkes
    • 1
  1. 1.Department of Oral Immunology and MicrobiologyGuy’s Hospital Medical and Dental SchoolLondonEngland

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