Passive Immunization with Antisera to Streptococcus Mutans in the Prevention of Caries in Rhesus Monkeys
Immunization with Streptococcus mutans in rhesus monkeys elicits both antibodies and cell-mediated immunity (1). Serum IgG antibodies to S. mutans have been consistently associated with protection against caries. A significant correlation was found between skin delayed hypersensitivity (DH) or the lymphoproliferative response and IgG but not IgM antibodies to S. mutans. This raised the possibility that the cell-mediated immune responses might be a measure of T-cell helper function (2). Although direct evidence for T-cell helper function is not yet available, this is probable, as IgG antibodies are thymus-dependent to a much greater extent than the IgM antibodies (3).
KeywordsDental Caries Transfer Factor Dental Plaque Carious Lesion Passive Immunization
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