The Effect of Cyclosporin a on Dental Caries in Rats Monoassociated with Actinomyces Viscosus NY 1

  • B. Guggenheim
  • A. Hefti
  • J. J. Burckhardt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)

Abstract

Numerous pathomechanisms have been proposed as relevant in periodontal disease (1). The T-cell triggered effector systems have been especially emphasized as the most important mediators of this particular chronic inflammation (2–4). It was therefore tempting to investigate whether T-cell suppression by a suitable antilymphocytic agent had a major influence on the establishment and progression of the disease.

Keywords

Arthritis Sucrose Cage Polysaccharide Cyclosporin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Grigsby, W. R. and Sabiston, C.B., J. Oral Pathol. 5: 175, 1976.PubMedCrossRefGoogle Scholar
  2. 2.
    Lehner, T., J. Oral Pathol. 1: 39, 1972.PubMedGoogle Scholar
  3. 3.
    Horton, J. E., Oppenheim, J. J. and Mergenhagen, S. E., J. Periodontol. 45: 351, 1974.PubMedCrossRefGoogle Scholar
  4. 4.
    Oppenheim, J. J. and Horton, J. E., in Comparative Immunology of the Oral Cavity (Edited by Mergenhagen, S. E. and Scherp, H. W.), p. 221, DHEW Publication, NIH, Bethesda, 1973.Google Scholar
  5. 5.
    Dreyfuss, M., Harri, E., Hofmann, H., Kobel, H., Pache, W. and Tscherter, H., Eur. J. Appl. Microbiol. 3:125, 1976.CrossRefGoogle Scholar
  6. 6.
    Borel, J. F., Feurer, C, Gubler, H. U. and Stähelin, H., Agents and Actions 6:468, 1976.PubMedCrossRefGoogle Scholar
  7. 7.
    Guggenheim, B. and Schroeder, H. E., Infect. Immun. 10: 565, 1974.PubMedGoogle Scholar
  8. 8.
    Borel, J. F., Feurer, C., Magnée, C. and Stähelin, H., Immunology 32: 1017, 1977.PubMedGoogle Scholar
  9. 9.
    Borel, J. F. and Wiesinger, D., in Regulatory Mechanisms in Lymphocyte Activation (Edited by Lucas, D. O.), p. 716, Academic Press, New York, 1977.Google Scholar
  10. 10.
    Borel, J. F., Immunology 31: 631, 1976.PubMedGoogle Scholar
  11. 11.
    Keyes, P. H., J. Dent. Res. 31:1088, 1958.Google Scholar
  12. 12.
    König, K. G., in Möglichkeiten der Kariesprophylaxe beim Menschen und ihre Untersuchung im kurzfristigen Rattenexperiment, Hans Huber, Bern/Stuttgart, 1966.Google Scholar
  13. 13.
    Regolati, B. and Hotz, P., Helv. Odont. Acta 16: 13, 1972.Google Scholar
  14. 14.
    König, K. G., Schmid, P. and Schmid, R., Archs. Oral Biol. 13: 13, 1968.CrossRefGoogle Scholar
  15. 15.
    Janossy, G. and Greaves, N. F., Clin. Exp. Immunol. 9:483, 1971.PubMedGoogle Scholar
  16. 16.
    Bowen, W. H., Cohen, B. and Colman, G., Brit. Dent. J. 139: 45, 1975.PubMedCrossRefGoogle Scholar
  17. 17.
    Lehner, T., Challacombe, S. J., Wilton, J.M.A. and Caldwell, J., Nature 264; 69, 1976.PubMedCrossRefGoogle Scholar
  18. 18.
    McGhee, J. R., Michalek, S. M., Webb, J., Navia, J. M., Rahman, A.F.R. and Legier, D. W., J. Immunol. 114: 300, 1975.PubMedGoogle Scholar
  19. 19.
    Taubman, M. A. and Smith, D. J., Infect. Immun. 9:1079, 1974.Google Scholar
  20. 20.
    Tanzer, J. M., Hageage, G. J. and Larson, R. H., Archs. Oral Biol. 18: 1425, 1973.CrossRefGoogle Scholar
  21. 21.
    Guggenheim, B., Mühlemann, H.R., Regolati, B. and Schmid, R., in Dental Plaque (Edited by McHugh, W. D.), E & S Livingstone, Edinburgh/London, 1970.Google Scholar
  22. 22.
    Burckhardt, J. J. and Guggenheim, B., Infect. Immun. 13: 1009, 1976.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • B. Guggenheim
    • 1
  • A. Hefti
    • 1
  • J. J. Burckhardt
    • 1
  1. 1.Department of Oral Microbiology and General Immunology, Dental InstituteUniversity of ZurichZurichSwitzerland

Personalised recommendations