I would like to ask Dr. Elson a question. Instead of postulating different T suppressor and T helper cells for the IgM and IgA precursors, couldn’t your results be equally explained by suggesting that expression of cytoplasmic immunoglobulins depends on the balance of T helpers and T suppressors and that the Peyer’s patches contained relatively fewer Con A inducible suppressors? A difference in sensitivity to a given balance of the Peyer’s patch IgA precursors and the splenic precursors may be a reason for the effects you observed. We have already shown that the Peyer’s patch IgA precursors are more secondary and can give rise to clones in allogeneic systems but the splenic IgA precursors are more primary and do not give rise to such clones. It seems to me that you could get the result by assuming differential sensitivity to ratios of T helpers and T suppressors.
KeywordsSialic Acid Primary Biliary Cirrhosis Secretory Component Pinocytotic Vesicle Myeloma Protein
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