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Discussion

  • Jerry R. McGhee
  • Jiri Mestecky
  • James L. Babb
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)

Abstract

I would like to ask Dr. Elson a question. Instead of postulating different T suppressor and T helper cells for the IgM and IgA precursors, couldn’t your results be equally explained by suggesting that expression of cytoplasmic immunoglobulins depends on the balance of T helpers and T suppressors and that the Peyer’s patches contained relatively fewer Con A inducible suppressors? A difference in sensitivity to a given balance of the Peyer’s patch IgA precursors and the splenic precursors may be a reason for the effects you observed. We have already shown that the Peyer’s patch IgA precursors are more secondary and can give rise to clones in allogeneic systems but the splenic IgA precursors are more primary and do not give rise to such clones. It seems to me that you could get the result by assuming differential sensitivity to ratios of T helpers and T suppressors.

Keywords

Sialic Acid Primary Biliary Cirrhosis Secretory Component Pinocytotic Vesicle Myeloma Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Jerry R. McGhee
    • 1
  • Jiri Mestecky
    • 1
  • James L. Babb
    • 1
  1. 1.Institute of Dental Research, Departments of Microbiology and Medicine, Comprehesive Cancer CenterUniversity of Alabama in BirminghamBirminghamUSA

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