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Induction of Secretory Antibodies in Humans Following Ingestion of Streptococcus Mutans

  • Jerry R. McGhee
  • Jiri Mestecky
  • Roland R. Arnold
  • Suzanne M. Michalek
  • Shirley J. Prince
  • James L. Babb
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)

Abstract

The finding that ingestion of bacterial antigen in animals and in man induces the appearance of s-IgA antibodies in colostrum and milk (1–5) strongly suggests that local stimulation of secretory glands is not required for this induction. This conclusion is reinforced by the observation of naturally-occurring antibody to such bacteria as Escherichia coli, Streptococcus pneumoniae and S. mutans in saliva, colostrum and milk. This study offers data which suggests that ingestion of S. mutans antigen by human volunteers induces the selective appearance of s-IgA antibody in salivary and lacrimal secretions in the absence of a detectable serum response.

Keywords

Streptococcus MUTANS Oral Immunization Antigen Ingestion Secretory Antibody Parotid Saliva 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Jerry R. McGhee
    • 1
    • 2
  • Jiri Mestecky
    • 1
    • 2
  • Roland R. Arnold
    • 1
    • 2
  • Suzanne M. Michalek
    • 1
    • 2
  • Shirley J. Prince
    • 1
    • 2
  • James L. Babb
    • 1
    • 2
  1. 1.Department of Microbiology and Institute of Dental ResearchUniversity of Alabama in BirminghamBirminghamUSA
  2. 2.Laboratory of Microbiology and Immunology, National Institute of Dental ResearchNational Institutes of HealthBethesdaUSA

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