Secretory IgA Antibodies to Enterobacterial Virulence Antigens: Their Induction and Possible Relevance

  • L. Å. Hanson
  • S. Ahlstedt
  • B. Carlsson
  • B. Kaijser
  • P. Larsson
  • I. Mattsby Baltzer
  • A. Sohl Åkerlund
  • C. Svanborg Edén
  • A.-M. Svennerholm
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)


The existence of local antibody-mediated immunity has been known for several decades (1–4). Knowledge about the special properties of secretory IgA (s-IgA) antibodies has defined antibody-mediated local immunity as an entity different and separate from systemic antibody-mediated immunity (5–7). The induction and role of s-IgA antibodies to virulence antigens of microbes infecting various mucous surfaces is now being studied and elucidated. The finding of Craig and Cebra (8) that Peyer’s patch lymphocytes can repopulate the intestinal mucosa of irradiated animals with IgA producing cells suggested that such cells may migrate also to other submucosal sites. New information has recently been added in this field by investigations on the migration, “homing”, of IgA producing cells from the Peyer’s patches to various exocrine glands (9,10). This brief review deals with the relation between the homing mechanism and the appearance and possible role of s-IgA antibodies to enterobacterial antigens in milk, saliva, urine and bronchial secretion.


Human Milk Acute Pyelonephritis Cholera Vaccine Pakistani Woman Serum Antibody Response 


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • L. Å. Hanson
    • 1
  • S. Ahlstedt
    • 1
  • B. Carlsson
    • 1
  • B. Kaijser
    • 1
  • P. Larsson
    • 1
  • I. Mattsby Baltzer
    • 1
  • A. Sohl Åkerlund
    • 1
  • C. Svanborg Edén
    • 1
  • A.-M. Svennerholm
    • 1
  1. 1.Department of Immunology and Department of General Bacteriology, Institute of Medical Microbiology and Department of PediatricsUniversity of GöteborgGöteborgSweden

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