Advertisement

Generation of Clonal and Isotype Diversity

  • Max D. Cooper
  • Hiromi Kubagawa
  • Larry B. Vogler
  • John F. Kearney
  • Alexander R. Lawton
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)

Abstract

A major consideration of this symposium concerns the processes involved in development of cells producing appropriate IgA antibodies in strategic locations within the body. Central to any satisfactory solution to this problem are answers to two basic questions: 1) how diverse clones of B cells, each of which produces antibodies of a single specificity, are generated in the first place, and 2) how some members of each clone make the decision to produce IgA antibodies. In this brief presentation we will concentrate on the phenotypic reflections of these genetic decisions as they occur at a cellular level of development. Since there are still unresolved controversies and overt gaps in knowledge of key events during this complex differentiation process, biases in our selection and interpretation of the available data are inevitable, but an attempt will be made to discern between facts and speculation.

Keywords

Cold Spring Harbor Cold Spring Harbor Laboratory Clonal Diversity Hemopoietic Stem Cell Immunoglobulin Isotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Metcalf, D. and Moore, M.A.S., in Hemopoietic Cells (Edited by Neuberger, A. and Tatum, E. L.) North-Holland Publishing Co., Amsterdam, 1971.Google Scholar
  2. 2.
    Adamson, J. W., Eialkow, P. J., Murphy, S., Prahl, J. F. and Steinmann, L., N. Engl. J. Med. 295 : 913, 1976.PubMedCrossRefGoogle Scholar
  3. 3.
    LeDouarin, N. M. and Jotereau, F. V., J. Exp. Med. 142: 17, 1975.PubMedCrossRefGoogle Scholar
  4. 4.
    Owen, J.J.T., Cooper, M. D. and Raff, M. C., Nature 249: 361, 1974.PubMedCrossRefGoogle Scholar
  5. 5.
    Gathings, W E., Lawton, A. R. and Cooper, M. D., Eur. J. Immunol., in press, 1978.Google Scholar
  6. 6.
    Raff, M. C, Megson, M., Owen, J.J.T. and Cooper, M.D., Nature 259: 224, 1976.PubMedCrossRefGoogle Scholar
  7. 7.
    Melchers, F., Andersson, J. and Phillips, R. A., in Cold Spring Harbor Symposia on Quantitative Biology, Vol. XLI, Origins of Lymphocyte Diversity, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1977.Google Scholar
  8. 8.
    Hayward, A. R., Simons, M., Lawton, A. R., Mage, R. G. and Cooper, M. D., in Developmental Immunobiology, (Edited by Solomar, J. B.), Elsevier/North-Holland Biomedical Press, Amsterdam, in press, 1978.Google Scholar
  9. 9.
    Owen, J.J.T., Wright, D. E., Habu, S., Raff, M. C. and Cooper, M. D., J. Immunol. 118: 2067, 1977.PubMedGoogle Scholar
  10. 10.
    Okos, A. J. and Gathings, W. E., Fed. Proc. 36: 1294, 1977.Google Scholar
  11. 11.
    Burrows, P. D., Kearney, J. F., Lawton, A. R. and Cooper, M. D., submitted.Google Scholar
  12. 12.
    Osmond, D. G. and Nossal, G.J.V., Cell. Immunol. 13: 132, 1974.PubMedCrossRefGoogle Scholar
  13. 13.
    Ryser, J-E. and Vassalli, P., J. Immunol. 113: 719, 1974.PubMedGoogle Scholar
  14. 14.
    Abney, E. R., Cooper, M. D., Kearney, J. F., Lawton, A. R. and Parkhouse, R.M.E., submitted.Google Scholar
  15. 15.
    Gelfand, M. G., Elfenbein, G. J., Frank, M. M. and Paul, W. E., J. Exp. Med. 139: 1128, 1974.Google Scholar
  16. 16.
    Kearney, J. F., Cooper, M. D., Klein, J., Abney, E. R., Park-house, R.M.E.and Lawton, A. R., J. Exp. Med. 146: 297, 1977.Google Scholar
  17. 17.
    Cambier, J. C., Vitetta, E. S., Kettman, J. R., Werzel, G. M. and Uhr, J. W., J. Exp. Med. 146: 107, 1977.PubMedCrossRefGoogle Scholar
  18. 18.
    Scott, D. W., Layton, J. E. and Nossal, G.J.V., J. Exp. Med., in press, 1978.Google Scholar
  19. 19.
    Metcalf, E. S. and Klinman, N. R., J. Exp. Med. 143: 1327, 1976.PubMedCrossRefGoogle Scholar
  20. 20.
    Nossal, G.J.V. and Pike, B. L., J. Exp. Med. 141: 904, 1975.PubMedGoogle Scholar
  21. 21.
    Kincade, P. W., Lawton, A. R., Bookman, D. E. and Cooper, M. D., Proc. Natl. Acad. Sci. (USA) 67: 1918, 1970.CrossRefGoogle Scholar
  22. 22.
    Lawton, A. R. and Cooper, M. D., in Contemporary Topics in Immunobiology (Edited by Cooper, M. D. and Warner, N. L.), Plenum Press, New York, 1974.Google Scholar
  23. 23.
    Manning, D. D., Manning, J. K. and Reed, N. D., J. Exp. Med. 144: 288, 1976.PubMedCrossRefGoogle Scholar
  24. 24.
    Raff, M. C., Owen, J.J.T., Cooper, M. D., Lawton, A. R., Megson, M. and Gathings, W. E., J. Exp. Med. 142: 1052, 1975.PubMedCrossRefGoogle Scholar
  25. 25.
    Sidman, C. L. and Unanue, E. R., Nature 257: 149, 1975.PubMedCrossRefGoogle Scholar
  26. 26.
    Munro, A. J. and Taussig, M., Nature.256: 103, 1975.PubMedCrossRefGoogle Scholar
  27. 27.
    Gronowicz, E. and Coutinho, A., Transplant. Rev. 24 : 3, 1975.PubMedGoogle Scholar
  28. 28.
    Huber, B., Gershon, R. K. and Cantor, H., J. Exp. Med. 145: 10, 1977.PubMedCrossRefGoogle Scholar
  29. 29.
    Roux, M. E., McWilliams, M., Phillips-Quagliata, J. M., Weisz-Carrington, P. and Lamm, M. E., J. Exp. Med. 146: 1311, 1977.PubMedCrossRefGoogle Scholar
  30. 30.
    Kearney, J. F., Cooper, M. D. and Lawton, A. R., J. Immunol. 117: 1567, 1976.PubMedGoogle Scholar
  31. 31.
    Burgois, A., Kitajima, K., Hunter, I. R. and Askonas, B. A., Eur. J. Immunol, 7: 151, 1977.CrossRefGoogle Scholar
  32. 32.
    Preud’homme, J. L., Eur. J. Immunol. 7 : 191, 1977.CrossRefGoogle Scholar
  33. 33.
    Klinman, N. R., Sigal, N. H., Metcalf, E. S., Pierce, S. K. and Gearhart, P. J., in Cold Spring Harbor Symposia on Quantitative Biology, Vol. XLI, Origins of Lymphocyte Diversity, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1977.Google Scholar
  34. 34.
    Lydyard, P. M., Grossi, C. E. and Cooper, M. D., J. Exp. Med. 144: 79, 1976.PubMedCrossRefGoogle Scholar
  35. 35.
    Raff, M. C., in Cold Spring Harbor Symposia on Quantitative Biology, Vol. XLI, Origins of Lymphocyte Diversity, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1977.Google Scholar
  36. 36.
    Lawton, A. R., Kearney, J. F. and Cooper, M. D., in Progress in Immunology III. Proceedings of the Third International Congress of Immunology (Edited by Cooper, G. N.), Academic Press, New York, in press, 1978.Google Scholar
  37. 37.
    Strayer, D. S., Cosenza, H., Lee, W.M.F., Rowley, D. A. and Köhler, H., Science 186: 640,.1974.PubMedCrossRefGoogle Scholar
  38. 38.
    Cooper, M. D., Cain, W. A., VanAlten, P. J. and Good, R. A., Int. Arch. Allergy Appl. Immunol. 35: 242, 1969.PubMedCrossRefGoogle Scholar
  39. 39.
    Kincade, P. W., Self, K. S. and Cooper, M. D., Cell. Immunol. 8: 93, 1973.PubMedCrossRefGoogle Scholar
  40. 40.
    Rudders, R. A. and Ross, R., J. Exp. Med. 142 : 549, 1975.PubMedCrossRefGoogle Scholar
  41. 41.
    van Boxel, J. A. and Buell, D. N., Nature 251: 443, 1974.PubMedCrossRefGoogle Scholar
  42. 42.
    Pernis, B., Forni, L. and Luzzati, A. L., in Cold Spring Harbor Symposia on Quantitative Biology, Vol. XLI, Origins of Lymphocyte Diversity, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1977.Google Scholar
  43. 43.
    Kearney, J. F., Lawton, A. R. and Cooper, M. D., in ICN-UCLA Symposium Proceedings, Immune System II: Regulation and Genetics, Vol. 8, (Edited by Sercarz, E., Herzenberg, L. A. and Fox, C. F.), Academic Press, in press, 1978.Google Scholar
  44. 44.
    Pierce, S. K. and Klinman, N. R., J. Exp. Med. 142: 1165, 1975.PubMedCrossRefGoogle Scholar
  45. 45.
    Gearhart, P. J., Nature 269: 812, 1977.PubMedCrossRefGoogle Scholar
  46. 46.
    Kearney, J. F. and Lawton, A. R., J. Immunol. 115: 677, 1975.PubMedGoogle Scholar
  47. 47.
    Bleux, C., Ventura, M. and Liacopoulos, P., Nature 267: 709, 1977.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Max D. Cooper
    • 1
  • Hiromi Kubagawa
    • 1
  • Larry B. Vogler
    • 1
  • John F. Kearney
    • 1
  • Alexander R. Lawton
    • 1
  1. 1.Departments of Pediatrics and Microbiology and the Comprehensive Cancer CenterUniversity of Alabama in BirminghamBirminghamUSA

Personalised recommendations