Cellular Aspects of the Murine Anti-Hapten IgA Response
Early experiments established the requirement for thymus derived (T) lymphocytes and bone marrow derived (B) lymphocytes for the generation of humoral antibody responses (1–3). In recent years our knowledge of the regulatory functions of T-cells with respect to B-cell differentiation has been expanded to reveal an intricate system, which in addition to cells, involves regulator genes and soluble factors (reviewed 4,5). The regulatory influence which T-cells exert on the stimulation of IgM, IgG (4,5) and more recently, IgE (6–8) is well defined. A similar understanding of the regulatory effect of T-cells on the IgA response would be useful in understanding the development of the secretory immune response.
KeywordsBone Marrow Cell Adoptive Transfer Thymus Cell Plaque Form Cell Myeloma Protein
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