Development of Humoral Antibody Following the Ingestion of Soluble Protein Antigen by Passively Immunized Animals

  • Richard M. Rothberg
  • Christian H. L. Rieger
  • Sumner C. Kraft
  • James V. Lustig
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)


Circulating antibodies against a variety of environmental antigens (1–6) appear in normal individuals after lymphoid tissues associated with mucosal surfaces are exposed to either the homologous or cross-reacting antigens. This immunization is one of the physiologic means by which mammals acquire protection against potential pathogens during early infancy (6–8). Prior to the development of such active immunity, the newborn is protected against the potentially harmful effects of these antigens by antibodies passively acquired from the mother. However, passive immunity may either suppress or enhance active immune responses, depending on quantitative factors and temporal relationships between the administration of antibody and the first exposure to the antigen (9). An understanding of the effects of passively transferred antibody on the amount and quality of antibody actively produced following the ingestion of antigen may provide insight into the effects of placentally transferred specific antibody on the immune response to the homologous antigen ingested during infancy.


Bovine Serum Albumin Lymphoid Tissue Active Immune Response Peripheral Lymphoid Tissue Environmental Antigen 


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Richard M. Rothberg
    • 1
  • Christian H. L. Rieger
    • 1
  • Sumner C. Kraft
    • 1
  • James V. Lustig
    • 1
  1. 1.Departments of Pediatrics and MedicineUniversity of ChicagoChicagoUSA

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