Immunologic Aspects of Human Colostrum and Milk: Interaction with the Intestinal Immunity of the Neonate
Human colostrum and milk contains T and B lymphocytes, macrophages and the major classes of immunoglobulins (1). The bulk of the immunoglobulins in colostrum and milk belong to the secretory (11S) IgA class (2,3). It has been suggested that the secretory IgA antibody activity found in the mammary glands and in colostrum is largely derived from the gut associated lymphoid tissue (4). Little or no information is available regarding the distribution of antibody producing cells and the levels of immunoglobulins in colostrum and milk at various times after onset of lactation. Fragmentary data are available on T-lymphocyte function and in vitro correlates of cell-mediated immunity in colostrum and milk (1,4). Little is known about the intestinal absorption of the immunoglobulins and cellular components in colostrum.
KeywordsMammary Gland Peripheral Blood Lymphocyte Breast Feeding Roswell Park Memorial Institute Purify Protein Derivative
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