Microbial Production of Essential Amino Acids with Corynebacterium Glutamicum Mutants

  • Kiyoshi Nakayama
  • Kazumi Araki
  • Hiroshi Kase
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 105)


Amino acids produced by microbial process are generally L-forms. The stereospecificity of the amino acids produced by fermentation makes the process advantageous compared with synthetic process. Microorganisms employed in microbial process for amino acid production are divided into 4 classes; wild-type strain, auxotrophic mutant, regulatory mutant and auxotrophic regulatory mutant. Using such mutants of Corynebacterium glutamicum all the essential amino acids but L-methionine are now being produced by “direct fermentation” from cheap carbon sources such as carbohydrate materials or acetic acid.


Essential Amino Acid Microbial Production Corynebacterium Glutamicum Auxotrophic Mutant Cane Molas 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Kiyoshi Nakayama
    • 1
  • Kazumi Araki
    • 1
  • Hiroshi Kase
    • 1
  1. 1.Tokyo Research LaboratoryKyowa Hakko Kogyo Co. Ltd.Machida-shi, TokyoJapan

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