Regulation of Calcium by Vascular Smooth Muscle Cellular Components

  • Julius C. Allen


In the case of smooth muscle in general and vascular smooth muscle in particular, the number of contractile or relaxing agents is quite large and all of them must ultimately, in some way, affect the interaction of Ca2+ with the regulatory component of the contractile protein apparatus. The specific nature of this interaction, the components of the regulatory proteins, and the specific mechanisms regulating Ca2+ in smooth muscle are, essentially, unknown. Consequently, this chapter will not try to elucidate specific Ca2+ involvement in drug actions, but will try to review recent biochemical data which have attempted to define the various mechanisms of Ca2+ regulation in this tissue. To date, no unifying hypothesis can be drawn regarding the mechanism(s) of regulation as can be done for other muscle tissue.


Smooth Muscle ATPase Activity Vascular Smooth Muscle Sarcoplasmic Reticulum Subcellular Fraction 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Julius C. Allen
    • 1
  1. 1.Baylor College of MedicineHoustonUSA

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