Prostaglandins, Calcium, and Cyclic Nucleotides in Stimulus-Response Coupling

  • Ronald P. Rubin
  • Suzanne G. Laychock


There is now little doubt that muscle contraction and secretory activity involve fundamentally similar processes, with an increase in free Ca2+ within the cytosol providing the critical link between membrane activation by a stimulus and the specific tissue response (Rubin, 1974a; Douglas, 1975a). On the one hand, Ca2+ is instrumental in initiating muscle myofilament contraction while, on the other hand, Ca2+ facilitates the fusion of secretory granule membranes with the cell membrane of exocytotic tissues. The fact that Ca2+ is a mediator in these two basic biological processes has prompted speculation that they share a similar molecular basis involving a contractile event (Poisner, 1970; Kuo and Coffee, 1976; Trifaro and Ulpian, 1976).


Adrenal Cortex Cyclic Nucleotide Guanylate Cyclase Adrenocortical Cell Putative Mediator 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Ronald P. Rubin
    • 1
    • 2
  • Suzanne G. Laychock
    • 1
    • 2
  1. 1.Departments of Pharmacology Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA
  2. 2.School of MedicineVanderbilt UniversityNashvilleUSA

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