Effects of Calcium on Adenylate Cyclase, as Part of the Ca2+-cAMP Feedback in Biological Communication

  • Gideon A. Rodan


Normal function of the organism depends on a continuous flow of intercellular and intracellular information, which coordinates all biological (biochemical) processes. A few common principles underlie the transfer of biological information: (1) the information is stored in the structure of macromolecules (nucleic acids, enzymes, contractile proteins and others); (2) the transfer of information is often triggered by the interaction of the macro-molecule with a small molecule; (3) if the information transfer involves energy expenditure (work), it is done at the expense of existing potential energy, such as the ion gradients across nerve membranes, and is initiated by removal of inhibition; and (4) the information transfer frequently involves amplification (multiple copies of a template, many product molecules generated by one molecule of activated enzyme, etc.).


Adenylate Cyclase Cyclic Nucleotide Adenylate Cyclase Activity Hill Coefficient Rous Sarcoma Virus 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Gideon A. Rodan
    • 1
  1. 1.Department of Oral BiologyUniversity of Connecticut School of Medicine and Dental MedicineUSA

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