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Calcium Related Basis of Action of Vascular Agents: Cellular Approaches

  • Frank R. Goodman

Abstract

It is well established in vascular smooth muscle (Bohr, 1973; Weiss, 1977) as well as in cardiac (Fozzard, 1977; Fleckenstein, 1977) and other types of muscle (Bianchi, 1975; Ebashi, 1977) that calcium serves as a link in the events leading from membrane depolarization to muscle contraction. However, the degree of dependence on the extracellular Ca2+ level varies greatly among the different types of muscle. For example, contractile responsiveness in skeletal muscle is less sensitive to changes in the extracellular Ca2+ concentration than are contractions obtained with cardiac muscle. These differences in the degree of dependence on extracellular Ca2+ have been related to the volume of sarcoplasmic reticulum (SR) in the tissue (Devine et al., 1972). Skeletal muscle has a large amount of SR (Lüllmann and Peters, 1977) in relation to the amount found in cardiac or smooth muscle. In skeletal muscle, depolarization of the transverse tubular element initiates a coupling step between the transverse tubular element and the SR, which, in turn, causes the release of Ca2+ important for contraction. In contrast, Ca2+ important for initiation of contraction in cardiac muscle originates from superficial sites which are in equilibrium with interstitial space Ca2+ (Langer, 1976). Thus, in skeletal muscle and, to some degree, in cardiac muscle both the manner in which Ca2+ is utilized for the initiation of the contractile response and the mechanism(s) by which drugs interfere with this process are well characterized (Fuchs, 1974; Bianchi, 1975).

Keywords

Smooth Muscle Vascular Smooth Muscle Sarcoplasmic Reticulum Leave Anterior Descend Contractile Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Frank R. Goodman
    • 1
  1. 1.Department of PharmacologyDow Chemical CompanyIndianapolisUSA

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