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Behavior of the Blood-Brain Barrier (BBB) in Cerebral Ischemia

  • K. Nishimoto
  • S. Kakari
  • H. Pappius
  • M. Spatz
  • J. T. WalkerJr.
  • I. Klatzo

Abstract

Although a stationary occlusion of an artery, as well as the introduction of an embolic obstruction into the cerebral circulation can both result in ischemic damage to the brain parenchyma, a number of observations indicate some profound differences regarding the effect of these two conditions on the behavior of the BBB. Whereas after occlusion of the carotid artery in the ger-bil the time of the BBB breakdown can be considerably delayed depending on the duration of ischemic insult (1,2), an abnormal permeability of the BBB to various tracers almost immediately follows the passage of emboli (4).

Keywords

Carotid Artery Basal Ganglion Cerebral Ischemia Evans Blue Ischemic Insult 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • K. Nishimoto
    • 1
  • S. Kakari
    • 1
  • H. Pappius
    • 1
  • M. Spatz
    • 1
  • J. T. WalkerJr.
  • I. Klatzo
    • 1
  1. 1.Laboratory of Neuropathology and Neuroanatomical Sciences, National Institute of Neurological and Communicative Disorders and StrokeNational Institutes of HealthBethesdaUSA

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