Short-Term Unilateral Ischemia in Gerbils: A Reevaluation

  • N. Murakami
  • W. D. Lust
  • A. B. Wheaton
  • J. V. Passonneau


Our previous studies on unilateral and bilateral ischemia in the gerbil have been primarly concerned with the sites directly affected by the loss of circulation. In these regions, the changes in brain metabolites, including energy reserves and cyclic nucleotides, have been pronounced (4, 8). In earlier studies with unilateral ischemia, there were little or no observable changes in these metabolites in the contralateral cortex (8, 11). However, Levy and Duffy (6) have recently demonstrated that there are changes not only in the contralateral cortex of affected gerbils but also in the ipsilateral cortex of animals not exhibiting positive neurological signs of ischemia, a condition which was completely ignored in our previous studies. It appears that the biochemical effects of an ischemic episode are variable depending upon the region of the brain investigated and perhaps on the neurological responses elicited. The intermediate range of responses in those areas not directly affected by the carotid artery occlusion is the subject of this paper.


Common Carotid Artery Neurological Sign Carotid Artery Occlusion Ischemic Episode Brain Metabolite 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • N. Murakami
    • 1
  • W. D. Lust
    • 1
  • A. B. Wheaton
    • 1
  • J. V. Passonneau
    • 1
  1. 1.Laboratory of Neurochemistry, National Institute of Neurological and Communicative Disorders and StrokeNational Institutes of HealthBethesdaUSA

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