Rem Sleep Deprivation: Effects on Incorporation of Inorganic Sulfate into Brain Acid Mucopolysaccharides

  • M. Rusić
  • V. Šušić
  • M. Levental
  • Lj. Rakić


The study was a search for sleep-related alterations in brain metabolism through observations on the incorporation of 35S-labeled sulfate into brain acid mucopolysaccharides (AMPS) of REM-sleep-deprived and sleeping rats.


Sleep Deprivation Uronic Acid Brain Protein Recovery Sleep Hexuronic Acid 
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  1. 1.
    Duncan, R., Henry, P., Karadzic, V., Mitchell, G., Pivik, T., Cohen, H. and Dement, W. (1968): Manipulation of the sleep-wakefulness cycle in the rat: A longitudinal study. Psychophysiology 4: 379.Google Scholar
  2. 2.
    Morden, B., Mitchell, G. and Dement, W. (1967): Selective REM sleep deprivation and compensation in the rat. Brain Reg. 5: 339–349.CrossRefGoogle Scholar
  3. 3.
    Ringertz, N. R. (1956): On the sulphate metabolism of the mouse brain. Exp. Cell Res. 10: 230–233.PubMedCrossRefGoogle Scholar
  4. 4.
    Robinson, J. D., Jr. and Green J. P. (1962): Sulfo-mucopolysaccharides in brain. Yale J. Biol. Med. 35: 248–256.PubMedGoogle Scholar
  5. 5.
    Stefanovich, V. and Gore, I. J. (1967): A micro-method for the determination of acid mucopolysaccharides in vascular tissue. J. Chromatography 31: 473–478.CrossRefGoogle Scholar
  6. 6.
    Boas, N. (1953): Method for the determination of hexosamines in tissues. J. Biol. Chem. 204: 553–563.PubMedGoogle Scholar
  7. 7.
    Bobillier, P., Sakai, K., Seguin, S. and Jouvet, M. (1971): Effects de la privation de sommeil sur l’incorporation d’acides aminés marqués dans les protéines cérébrales du rat. C. R. Soc. Biol. 165: 118–123.Google Scholar
  8. 8.
    Reich, P., Driver, J. and Karnovsky, M. (1967): Sleep: Effects on incorporation of inorganic phosphate into brain fractions. Science 157: 336–338.PubMedCrossRefGoogle Scholar
  9. 9.
    Mark, J., Godin, Y. and Mandel, P. (1969): Biosynthesis of asDartic, glutamic, -aminobutyric acids and glutamine in brain of rats deprived of total sleep or of paradoxal sleep. J. Neurochem. 16: 1263–1272.PubMedCrossRefGoogle Scholar
  10. 10.
    Shapot, V. S. (1957): Brain metabolism in relation to the functional state of the central nervous system. In: Metabolism of the Nervous System. D. Richter ed. Pergamon Press, New York, 257–262.Google Scholar
  11. 11.
    Brodskii, V., Gusatinskii, V. N. Ya, Kogan, A. B., and Nechaeva, N. V. (1974): Variations in the intensity of K leucine incorporation into proteins during slow-wave and paradoxical phase of natural sleep in the cat associative cortex. Dokl. Akad. Nauk. SSSR 215: 748–750.PubMedGoogle Scholar
  12. 12.
    Bobillier, P., Sakai, F., Sequin, S. and Jouvet, M. (1974): The effect of sleep deprivation upon in vivo and in vitro incorporation of tritiated amino acids into brain proteins in the rat at three different age levels. J. Neurochem. 22: 23–31.CrossRefGoogle Scholar
  13. 13.
    Marovici, N., Stoica, J., Petrescu, A. and Marcovici, G. (1964): Effect of hyaluronidase on normal and experimentally damaged brain. Rev. Roumaine Neurol. I: 37–47.Google Scholar
  14. 14.
    Young, I. J. (1963): Reversible seizures produced by neuronal hyaluronic acid depletion. Exp. Neurol. 8: 195–202.Google Scholar
  15. 15.
    Bowers, M. B., Kartmann, E. L. and Freedman, D. X. (1966): Sleep deprivation and brain acetylcholine. Science 153: 1416–1417.PubMedCrossRefGoogle Scholar
  16. 16.
    Cohen, K. B. and Dement, W. C. (1965): Sleep: Changes in threshold of ECS in rat after deprivation of the “paradoxical” phase. Science 150: 1318–1319.PubMedCrossRefGoogle Scholar
  17. 17.
    Cohen, K. B., Thomas, J. and Dement, W. C. (1970): Sleep stages: REM deprivation and electroconvulsive threshold in the cat. Brain Res. 19: 317–321.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • M. Rusić
    • 1
    • 2
  • V. Šušić
    • 1
    • 2
  • M. Levental
    • 1
    • 2
  • Lj. Rakić
    • 1
    • 2
  1. 1.Department of NeurochemistryInstitute for Biological ResearchBelgradeYugoslavia
  2. 2.Department of Physiology, Medical SchoolUniversity of BelgradeBelgradeYugoslavia

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