Some Mechanisms of Epileptic Activity Generalization

  • V. M. Okujava


Epileptic activity induced in a definite cerebral focus may remain localized for some long periods of time. On the other hand, epileptic activity evoked in one point may easily spread to other brain regions thus leading to extensive generalization. But even in the first case, when focal epileptic activity is observed, the volleys originating from the focus naturally exert their influence upon other anatomically more or less closely connected brain regions.


Corpus Callosum Epileptic Activity Symmetrical Point Opposite Hemisphere Epileptogenic Focus 


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  1. 1.
    Ajmone-Marsan, C. (1963): Unitary analysis of projected epileptiform discharges. Electroen. Clin. Neurophysiol. 15: 197–208.CrossRefGoogle Scholar
  2. 2.
    Erickson, T.C. (1940): Spread of the epileptic discharge. An experimental study of the afterdischarge induced by electrical stimulation of the cerebral cortex. Archs. Neurol. Psychiatr., Chicago, 43: 429–452.Google Scholar
  3. 3.
    Grafstein, B. (1959): Organization of callosal connections in suprasylvian gyrus of cat. J. Neurophysiol., 22: 504–515.PubMedGoogle Scholar
  4. 4.
    Guerrero-Figuerra, R., Barros, A., Heath, R.G., Gonsales, G. (1964): Experimental subcortical epileptiform focus. Epilepsia, 5: 112–139.CrossRefGoogle Scholar
  5. 5.
    Holubar, J. (1965): Mode of activation of the mirror focus initiated by local penicillin application to the contralateral cerebral cortex in rats. Physiol, bohemoslovaca, 14: 509–511.Google Scholar
  6. 6.
    Holubar, J. (1966): Different mode of activation of foci. The penicillin and mirror cortical foci in rats. In: Z. Servit (ed.). Comparative and Cellular Pathophysiology of Epilepsy. Amsterdam.Google Scholar
  7. 7.
    Isaakson, R.L., Schwartz, H., Persoff, E., Pinson, L. (1971): The role of the corpus callosum in the establishment of areas of secondary epileptiform activity. Epilepsia, 12: 133–146.CrossRefGoogle Scholar
  8. 8.
    Kopeloff, N., Kennard, M.A., Pacella, B.L., Kopeloff, L.M., Chusid, S.G. (1950): Section of corpus callosum in experimental epilepsy in the monkey. Arch. Neurol. Psychiatr. 63: 719–727.Google Scholar
  9. 9.
    Matsumoto, H., Ajmone Marsan, C. (1964): Cortical cellular phenomena in experimental epilepsy: interictal manifestations. Expl. Neurol. 9: 286–32 6.CrossRefGoogle Scholar
  10. 10.
    Morrell, F. (1960): Secondary epileptogenic lesions. Epilepsia. 1: 538–560.PubMedCrossRefGoogle Scholar
  11. 11.
    Mosidze, V.A., Rishinashvili, R.S., Kevanischvili, Z. Sh. (1967): On the pathways of transmission of strychnine discharges between cerebral hemispheres. Bull. Acad. Sci. of the G.S.S.R., 48: 201–206 (in Russian).Google Scholar
  12. 12.
    Mosidze, V.M., Rishinashvili, R.S., Kevanishvili, Z. Sh., Akbardia, K.K. (1972); The Split Brain. “Metsniereba”, Tbilisi (in Russian).Google Scholar
  13. 13.
    Okujava, V.M. (1967): Characteristic of epileptic activity of cortical neurons. In: Problems of Modern Neurology. Tbilisi (in Russian).Google Scholar
  14. 14.
    Okujava, V.M. (1969): Basic Neurophysiological Mechanisms of Epileptic Activity. “Ganatleba”, Tbilisi (in Russian).Google Scholar
  15. 15.
    Okujava, V.M., Chipashvili, S.A. (1973): On the role of callosal and extracellular connections in inter-hemispheric spread of epileptic activity. The Korsa-kov J. Neurol. Psychiatr. 11: 1679–1684 (in Russian).Google Scholar
  16. 16.
    Penfield, W., Jasper, H. (1954): Epilepsy and functional anatomy of the human brain. Little Brown & Co. Boston.Google Scholar
  17. 17.
    Shelikhov, V.N. (1960): Electrophysiological study of the role of subcortical structures in generalization of excitation in the cerebral cortex. The Korsakov J. Neurol. Psychiat. 2: 145–149 (in Russian).Google Scholar

Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • V. M. Okujava
    • 1
  1. 1.Institute of Clinical and Experimental NeurologyTbilisiU.S.S.R

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