Pathophysiology of Cerebral Ischemia

  • K.-A. Hossmann


The limiting factor for the reanimation of organisms following cardio-circulatory arrest is, in general, the anoxic vulnerability of the brain. The misrelationship between energy consumption and energy production is the reason for the high sensitivity of the brain. The brain has a high metabolic activity even under rest conditions: cerebral blood flow is about 50 ml/100 g/min, and oxygen consumption more than 3 ml/100 g/min. Brain energy requirements are approximately 8 cal/100 g/min, and are covered almost exclusively by oxidation of glucose which has to be continuously transported from the circulating blood into the brain.


Cerebral Blood Flow Cerebral Ischemia Revival Time Total Ischemia Barbiturate Anaesthesia 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • K.-A. Hossmann
    • 1
  1. 1.Max-Planck-Institut für HirnforschungCologne-MerheimW. Germany

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