Brain Microvessels: Glucose Metabolizing Enzymes in Ischemia and Subsequent Recovery

  • B. M. Djuričić
  • B. B. Mršulja


Hypoxia (arterial pO2 reduction) and ischemia (a critical degree of the brain tissue hypoperfusion) can deprive central nervous system cells of the oxygen supply which they require for normal function. In addition, ischemia deprives the brain of glucose, amino acids and other blood constituents passing the blood-brain barrier. Among other organs, the brain is unique in requiring a constant glucose and oxygen supply. With the restriction of the blood supply to the brain, the main sources of energy production are ATP, creatine phosphate, and glycogen (17). However the concentration of these brain metabolites falls rapidly following the onset of ischemia as produced in gerbils (13, 16, 18, 22).


Brain Parenchyma Pyruvate Kinase Mongolian Gerbil Subsequent Recovery Global Cerebral Ischemia 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • B. M. Djuričić
    • 1
  • B. B. Mršulja
    • 1
  1. 1.Laboratory for Neurochemistry, Institute of BiochemistryFaculty of MedicineBelgradeYugoslavia

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