Biochemical Aspects of Cerebral Edema

  • A. Baethmann
  • W. Oettinger
  • W. Rothenfusser
  • R. Geiger


Biochemical research on cerebral edema has certainly advanced the understanding of this complex condition. Biochemistry has been of great use in defining the different manifestations of this entity. Chemical investigations are probably more suitable than other methods to quantify the amount of edema in brain tissue, and to measure the effect of edema treatment. Since the pioneering work of Stewart-Wallace, Elliott and Jasper, and Pappius and co-workers, considerable material on the chemistry and biochemistry of brain edema has been published, supporting the existence of the two major prototypes described by Klatzo (10, 18, 30, 31, 43). Representative studies concern, for example: (1) the chemical composition of edematous tissue, (2) the edema fluid proper, (3) the distribution of edema in the tissue, and (4) the metabolic response of brain tissue to edema. Furthermore, investigations on chemical tissue or plasma factors promoting edema formation and persistence may be included in this subject. Obviously, a discussion of this material cannot be comprehensive within the scope of this brief introduction. Instead, a few aspects considered particularly significant will be emphasized.


White Matter Cerebral Edema Biochemical Aspect Cold Injury Edema Fluid 


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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • A. Baethmann
    • 1
  • W. Oettinger
    • 1
  • W. Rothenfusser
    • 1
  • R. Geiger
    • 1
  1. 1.Institute for Surgical Research, Department of SurgeryUniversity of MunichMunichW. Germany

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