Transport Phenomena in Cerebral Ischemia
The primary sequelae of cerebral ischemia are due to the lack of adequate blood circulation, which is the cause of insufficient supply of oxygen and nutrients to the brain. This circulatory disturbance is also one of the greatest obstacles to direct in vivo studies of processes involved in the transport of substrates into and out of the brain. Therefore, our previous investigations concerned with glucose transport in cerebral ischemia were performed at various periods following the reestablishment of cerebral blood circulation (11, 12, 14). Moreover, these limitations on the in vivo studies and the fact that the observed transport phenomena could have occurred in one or more sites such as capillary endothelium, glia and neurons have led so far to separate investigations of the cerebral microvessels and synapto-somes function.
KeywordsCerebral Ischemia Neutral Amino Acid Brain Uptake Carotid Artery Occlusion Bilateral Common Carotid Artery Occlusion
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