Biochemical and Genetic Studies on Sugar Transport in Bacteria
The mechanism of action of the semipermeable membrane is one of the fundamental problems in biology; this organelle distingushes between solutes of similar chemical structures and transports and retains those required for cell metabolism while removing undesirable metabolites. Perhaps the most important contribution to the understanding of the mechanism has been the application of bacterial genetics to the problem (1). These studies showed for the first time that membrane proteins (’permeases’) under specific genetic control were responsible for transport of carbohydrates across the cell membrane. Subsequent work has been aimed at isolating and characterizing the permease proteins, and in attempts to determine the mechanism(s) by which metabolic energy is coupled to the membrane-bound permeases.
KeywordsHistidine Residue Sugar Transport Semipermeable Membrane Similar Chemical Structure Phosphotransferase System
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