Surface Changes and Growth of Virus Transformed Cells
The idea that the abnormal social behaviour of cancer cells may be due to changes in their surfaces has stimulated research over a long period, but until recently it has been difficult to interpret the findings through lack of adequate comparability with appropriate normal cells. It is now possible however, to use cloned cell lines which can be rapidly and reliably transformed by various tumour viruses so that normal and transformed progeny from the same original parent cell can be compared under a variety of growth conditions.
KeywordsWheat Germ Agglutinin Saturation Density Rous Sarcoma Virus Serum Growth Factor Time Lapse Cinematography
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- Clarke, G.D. and Stoker, M.G.P. Ciba Fndtn. Symp. “Growth control in cell cultures” (1971) Eds. G.E.W. Wostenholme and Julie Knight (in Press)Google Scholar
- Cline, M. and Livingston, D.C. Nature 1971 (in Press)Google Scholar
- Foster, D.O. and Pardee, A.B. J. Biol. Chem. 244, 2675 (1969)Google Scholar
- Habel, K. Proc. Soc. Exp. Biol. N.Y. 106, 722 (1961)Google Scholar
- O’Neill, C.J. Cell Sci. 3, 405 (1968)Google Scholar
- Sjogren, H.O., Hellstrom, I. and Klein, G. Cancer Res. 21, 329 (1961)Google Scholar
- Taylor-Papadimitriou, J. and Stoker, M. Int. J. Cancer (in Press)Google Scholar
- Temin, H. Nature 1971 (in Press)Google Scholar