Luminescence Techniques in Drug Analysis

  • J. Arthur
  • F. de Silva
Part of the Progress in Analytical Chemistry book series (PAC)


Studies on the pharmacokinetics of a drug, i.e., absorption, distribution, metabolism, and elimination, and the correlation of therapeutic effectiveness with blood concentration requires a suitably sensitive and specific means of chemical analysis. The development of potent drugs has significantly reduced the therapeutic doses required for the maintenance of clinical efficacy. The quantitation of blood concentrations resulting from these low doses demands highly sophisticated analytical methods capable of accurate and precise quantitation with nanogram (10−9 g) to picogram (10−12 g) sensitivity (1). The majority of the drugs in clinical use today are organic molecules containing aromatic “benzenoid” or heterocyclic ring systems containing specific functional groups which impart intrinsic analytical properties to the compound.


Intrinsic Fluorescence Drug Analysis Phosphorescence Spectrum Fluorescent Derivative Dansyl Chloride 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • J. Arthur
    • 1
  • F. de Silva
    • 1
  1. 1.Dept. of Biochemistry and Drug MetabolismHoffmann-La Roche Inc.NutleyUSA

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