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Parathyroid Hormone: Structure and Immunoheterogeneity

  • Claude E. Arnaud
  • H. Bryan BrewerJr.
Part of the Progress in Analytical Chemistry book series (PAC)

Abstract

During the past 5 years there has been a great increase in our understanding of the chemistry, biosynthesis, secretion, and pathophysiology of parathyroid hormone (PTH). PTH has been shown by Hamilton, Cohn, Kemper, and colleagues1–4 to be synthesized as a precursor with a molecular weight of approximately 12,000. Structural studies of the bovine pro-parathyroid hormone (pro-PTH) have shown six additional amino acid residues attached to the NH2-terminal end of the molecule.5 Because amino acid compositional data suggest that pro-PTH has amino acid residues not yet accounted for by this hexapeptide sequence, the possibility that there is an additional sequence of amino acids attached to the COOH-terminal region is now being considered.6,7 It is likely that the pro-PTH is converted, in the parathyroid gland, to the storage form of the hormone, an 84 amino acid polypeptide with a molecular weight of 9,500. It is not known presently if pro-PTH is released into the circulation.

Keywords

Parathyroid Hormone Serum Parathyroid Hormone Serum iPTH Human Parathyroid Hormone Electron Impact Spectrum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • Claude E. Arnaud
    • 1
    • 2
  • H. Bryan BrewerJr.
    • 1
    • 2
  1. 1.Mineral Research Laboratory and the Department of Endocrine ResearchMayo Clinic and Mayo FoundationRochesterUSA
  2. 2.National Institutes of HealthBethesdaUSA

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