Applications of Combined Gas Chromatography-Mass Spectrometry in Clinical Chemistry

  • John Roboz
Part of the Progress in Analytical Chemistry book series (PAC, volume 176)


The combination of gas-liquid chromatography and mass spectrometry, together with computerization, has created a highly efficient tool for the multicomponent analysis of very low concentrations of a variety of constituents in physiological fluids and tissues. Gas chromatography is used to separate and quantify the compounds of interest, and spectrometry is used to confirm the identity of known or suspected constituents and to determine the identity and structure of unexpected constituents when encountered. The computer provides rapid and accurate acquisition and reduction of data, and may eventually also be used for interpretation and translation of chemical information into biological information.


Bile Acid Bile Duct Ligation High Resolution Mass Spectrometry Maple Syrup Urine Disease Pyroglutamic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • John Roboz
    • 1
  1. 1.Department of ChemistryThe Mount Sinai HospitalNew YorkUSA

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