Column Packings and Efficiency in High Pressure Liquid Chromatography

  • Karl J. Bombaugh
Part of the Progress in Analytical Chemistry book series (PAC, volume 176)


Recent advances in high pressure liquid chromatography have been brought about by a better understanding of the column packing, particularly to the effect of particle size on efficiency at high carrier velocity. It has now become an accepted principle that the way to achieve high speed in liquid chromatography is to use small particle diameter packing (1, 2, 3). Since the principle was first reported by such early workers as Huber (4), Snyder (5) and Scott (6), the definition of the word small has changed, and continues to change as column packing technology develops. Each new development has a tendency to supercede previous work to such an extent that we often lose perspective. It is, therefore, the purpose of this work to attempt to review new developments in packing technology in light of earlier developments, and, thereby, to understand what it is that makes high pressure column chromatography possible and to propose some considerations for evaluating and optimizing LC performance.


High Pressure Liquid Chromatography Column Packing Column Length Peak Capacity Plate Height 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Karl J. Bombaugh
    • 1
  1. 1.Chromatec, Inc.AshlandUSA

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