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Effect of Antigen on Localization of Immunologically Specific B Cells

  • N. M. Ponzio
  • J. M. Chapman
  • G. J. Thorbecke
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73B)

Abstract

Injection of antigen, either intravenously (i.V.), intraperi-toneally (i.p.) or locally, can enhance temporarily the influx of lymphoid cells into antigen-containing sites (2,3,4,6,7,10,11,16,17, 22,27,29,30,35). This has been examined early, usually only 24 to 48 hr, rarely as late as 72 hr after antigen (35). In many cases, a nonspecific increase of T cells (4,16) and/or macrophages (22) is involved, but a specific retention of T cells (3,11,30) and/or B cells (6,7,10,27,29,35) has also been shown. Homing of cells into allografts or sites of delayed reactions is mainly nonspecific as has been reviewed by McCluskey (22).

Keywords

Spleen Cell Drain Lymph Node Specific Retention Antigen Injection Immunologically Specific 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • N. M. Ponzio
    • 1
  • J. M. Chapman
    • 1
  • G. J. Thorbecke
    • 1
  1. 1.New York University School of MedicineNew YorkUSA

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