Modulation of the Expression of a Secondary IgG Antihapten Response In Vitro
Despite several observations which indicate that lymphocytes originally producing IgM may switch to the production of IgG (9,6) some investigators still term the switch hypothetical (10). Thus the significance of these observations to antigen driven immune processes remains unclear. It is possible to view the single cell M → G switch as one which occurs during ontogeny (6), and presumably is not antigen and to view subsequent shifts in antibody class during immunization as reflections of antigenic influences on the expression of precommitted percursor cells. This raises the question of how antigen influences expression of Ig classes; antibody and interacting cells or cell products have all been implicated in the regulatory process, but again their precise role remains un-elucidated (10, 7, 18, 8).
KeywordsSpleen Cell Plaque Assay Secondary Response Antigen Dose Secondary Immune Response
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