Interaction of Macrophages with Tumor Cells
Macrophages obtained from animals injected with certain facultative intracellular bacteria and protozoa will kill or inhibit the growth of tumor cells in vitro (1,3). These activated macrophages are capable of selective cytolysis of neoplastic target cells under in vitro conditions in which non-neoplastic target cells are spared and grow to confluency. In contrast, macrophages obtained after injection of sterile inflammatory stimulants, such as thioglycollate or peptone, are ineffective in killing tumor cells. Furthermore, macrophages obtained from normal unstimulated mice are also not cytotoxic (2).
KeywordsPeritoneal Lavage Kill Tumor Cell Nutrient Depletion Tumor Cell Lysis Tumor Cell Density
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- 3.Hibbs, J.B., Jr., Lambert, L.H., Jr. and Remington, J.S., Nature, 235 (1972) 48.Google Scholar