In Vitro Tumor Growth Inhibition by Syngeneic Lymphocytes and/or Macrophages

  • I. J. Fidler
  • D. E. Peterson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73B)


We (3) have recently confirmed the hypothesis by Prehn (13) that the normal immune response to neoplasia might have a dual role. This hypothesis suggests that during the early development of cancer or with weakly immunogenic, transplantable tumors, the cell-mediated response might directly stimulate rather than inhibit tumor growth. Our studies (3) reported the results of the interaction of normal, sensitized and concanavalin A-stimulated syngeneic, allogeneic, and/or xenogeneic lymphocytes with the B16 melanoma, C57BL/6 and/or A mouse embryo cells in an in vitro colony inhibition-stimulation system. Specifically sensitized lymphocytes at ratios up to 1000:1 repeatedly and significantly enhanced the growth of the target cells. At higher lymphocyte ratios, target cell inhibition occurred.


Inhibit Tumor Growth Immunize Mouse Peritoneal Exudate Cell Mouse Embryo Cell Normal Immune Response 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • I. J. Fidler
    • 1
  • D. E. Peterson
    • 1
  1. 1.NCI-Frederick Cancer Research CenterFrederickUSA

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