In Vitro Tumor Growth Inhibition by Syngeneic Lymphocytes and/or Macrophages
We (3) have recently confirmed the hypothesis by Prehn (13) that the normal immune response to neoplasia might have a dual role. This hypothesis suggests that during the early development of cancer or with weakly immunogenic, transplantable tumors, the cell-mediated response might directly stimulate rather than inhibit tumor growth. Our studies (3) reported the results of the interaction of normal, sensitized and concanavalin A-stimulated syngeneic, allogeneic, and/or xenogeneic lymphocytes with the B16 melanoma, C57BL/6 and/or A mouse embryo cells in an in vitro colony inhibition-stimulation system. Specifically sensitized lymphocytes at ratios up to 1000:1 repeatedly and significantly enhanced the growth of the target cells. At higher lymphocyte ratios, target cell inhibition occurred.
KeywordsInhibit Tumor Growth Immunize Mouse Peritoneal Exudate Cell Mouse Embryo Cell Normal Immune Response
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