Host Protection by Cell-Mediated and by Humoral Immunity in Malignancy
There is a complex and incomplete understanding of relationship between the immune system and malignancy. It is clear from many experimental systems that both cell-mediated immunity and the antibody-forming system can inhibit tumor development. There are also clinical data supporting such a host-protective function for immunity (3,6,12). However, the biological role of the immunological “surveillance” mechanisms in the development of spontaneous tumors remains to be determined (19). The surveillance concept was originally formulated with cell-mediated immunity in mind (24), however, it has become increasingly clear in the past years that the antibody forming system can also exert a powerful host-protective influence in vivo (9,15) and in vitro (8,17). The potential of the mononuclear phagocyte system alone, or in conjunction with other immunological defense mechanisms in tumor protection, is also well documented in these proceedings and elsewhere (5,10).
KeywordsHumoral Immunity Immune Serum Mononuclear Phagocyte System Tumor Frequency Tumor Cure
Unable to display preview. Download preview PDF.
- 1.Alexander, P., Cancer Res., 34 (1974) 2082.Google Scholar
- 3.Burnet, F.M., Immunological Surveillance, Pergamon Press, Oxford, (1970).Google Scholar
- 5.Evans, R., Cox, H. and Alexander, P., Proc. Soc. Exp. Med., 143 (1973) 259.Google Scholar
- 9.Hersey, P., Brit. J. Cancer, 28 (1973) 11.Google Scholar
- 10.Hibbs, J.B., Jr., Lambert, L.H., Jr. and Remington, J.S., Nature, 235 (1972) 48.Google Scholar
- 12.Klein, G., Immunological surveillance against neoplasia, Academic Press, New York, (1973–1974) 71.Google Scholar
- 13.Lam, K.M. and Linna, T.J., Fed. Proc., 34 (1975) 852.Google Scholar
- 16.Morrison, D.F., Multivariate Statistical Methods, McGraw-Hill, New York, (1967).Google Scholar
- 17.Perlman, P., Perlman, H. and Wigzell, H., Transplant Rev., 13 (1973) 91.Google Scholar
- 22.Svoboda, J., Chyle, P., Simkovic, D. and Hilgert, I., Folia Biol., 9 (1963) 77.Google Scholar
- 24.Thomas, L., Cellular and humoral aspects of hypersensitive states, (Ed. H.S. Lawrence), Hoeber-Harper, New York, (1959) 529.Google Scholar
- 25.Thompson, K.D. and Linna, T.J., Nature, 245 (1973) 10.Google Scholar