Host Protection by Cell-Mediated and by Humoral Immunity in Malignancy

  • T. J. Linna
  • C. Hu
  • K. M. Lam
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73B)


There is a complex and incomplete understanding of relationship between the immune system and malignancy. It is clear from many experimental systems that both cell-mediated immunity and the antibody-forming system can inhibit tumor development. There are also clinical data supporting such a host-protective function for immunity (3,6,12). However, the biological role of the immunological “surveillance” mechanisms in the development of spontaneous tumors remains to be determined (19). The surveillance concept was originally formulated with cell-mediated immunity in mind (24), however, it has become increasingly clear in the past years that the antibody forming system can also exert a powerful host-protective influence in vivo (9,15) and in vitro (8,17). The potential of the mononuclear phagocyte system alone, or in conjunction with other immunological defense mechanisms in tumor protection, is also well documented in these proceedings and elsewhere (5,10).


Humoral Immunity Immune Serum Mononuclear Phagocyte System Tumor Frequency Tumor Cure 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • T. J. Linna
    • 1
  • C. Hu
    • 1
  • K. M. Lam
    • 1
  1. 1.Temple University School of MedicinePhiladelphiaUSA

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