RES Blockade: Effects on Immunity and Tolerance
The cells of the reticuloendothelial system (RES) are involved in adoptive immunity toward microbial pathogens as well as “endogenous” parasites represented by malignant cells. Macrophages are considered the major cell type in the RES which “digests” and/or processes antigens, especially particulate ones (7, 8, 17, 19). The importance of such “antigen-processing” cells for specific antibody formation is now widely accepted. Non-specific as well as specific activities of macrophages are thought to be important in many types of immune responses (1, 2, 4, 9, 17). In this regard, experimental models designed to study macrophage function have involved the “inactivation” of macrophage function by chemical, physical, and even immunologic methods. For example, removal of macrophages from lymphoid cell suspensions by adsorption procedures or treatment with anti-macrophage serum often markedly reduces immunologic reactivity of the remaining cell populations (7, 17–19).
KeywordsLymphoid Cell Carbon Particle Antibody Formation Sheep Erythrocyte Challenge Immunization
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