Biological and Pathological Characteristics in Mouse Lines with Large Differences in Leukocyte Counts

  • C. K. Chai
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73B)


Experimental inquiry of quantitative characters of polygenic basis has been seen to contain many practical implications for agricultural programs, and to provide explanations for microevolution. Depending on the traits and organisms under investigation, study of quantitative genetic variations can also have practical applications in medicine. Gowen (6), for instance, may have been the first to experimentally demonstrate the genetic influences of disease resistance and susceptibility by selectively breeding mice for differences in resistance to typhoid organisms. Recently, Biozzi, et al. (1) selectively bred for differences in response to sheep red blood cells in mice, and they produced lines differing in a number of immunological parameters. These differences were attributed to the action of a large number of genes. This work provided a strong basis for the presence of the polygenic system in the immune response.


Leukocyte Count Amyloid Deposition Amyloid Fibril Inguinal Lymph Node Reticular Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Biozzi, G.C., Stiffel, C., Mouton, D., Bouthillier, Y. and Decreusefon, C., J. Exp. Med., 135 (1972) 1071.PubMedCrossRefGoogle Scholar
  2. 2.
    Chai, C.K., Genet. Res., 8 (1966) 125.PubMedCrossRefGoogle Scholar
  3. 3.
    Chai, C.K., J. Hered., (1975) in press.Google Scholar
  4. 4.
    Chai, C.K., Farley, T. and Morang, P., J. Lab. Clin. Med., 72 (1968) 165.PubMedGoogle Scholar
  5. 5.
    Dunn, T.B., J. Nat. Cancer Inst., 14 (1954) 1281.PubMedGoogle Scholar
  6. 6.
    Gowen, J., J. Infect. Dis., 73 (1943) 40.CrossRefGoogle Scholar
  7. 7.
    Janigan, D.T., Amer. J. Pathol., 47 (1965) 159.Google Scholar
  8. 8.
    Kaliss, N. and Chai, C.K., J. Reticuloendothel. Soc., 16 (1974) 330.PubMedGoogle Scholar
  9. 9.
    Silver, D. and Chai, C.K., J. Immunol., 115 (1975) 462.PubMedGoogle Scholar
  10. 10.
    Teilum, G., Acta. J. Pathol. Microbiol., 61 (1964) 21.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • C. K. Chai
    • 1
  1. 1.The Jackson LaboratoryBar HarborUSA

Personalised recommendations