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Immunological Tolerance: New Parameters for B-Cell Tolerance in Vitro

  • E. Diener
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73B)

Abstract

Before expanding on the ramifications of the mechanisms of immune tolerance, I will briefly describe the meaning of the term, in the context of this presentation. According to its original meaning tolerance defines the state of specific unresponsiveness to a secondary antigenic challenge. More than ever before have we become aware that the above definition of tolerance is an operational one and in no way reflects the basic mechanisms which underlie the phenomenon of unresponsiveness. Although the evidence is strong that one form of tolerance exists as a result of specific cell mediated suppression of immunocompetence (38), there is still sufficient justification to have us consider the more conservative concept of antigen induced functional deficiency at the level of the immunocompetent cell per se. Admittedly, the variety of current explanatory concepts concerning this type of tolerance may reflect the absence of solid analytical data on the subject rather than confirm a comprehensive body of experimental evidence. In spite of this deficiency, it has nevertheless been possible to define some of the conditions under which tolerance may be induced at the cellular and the molecular level in vitro (20).

Keywords

Tolerance Induction Immunocompetent Cell Immunological Tolerance Antigen Concentration Antigen Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • E. Diener
    • 1
  1. 1.University of AlbertaEdmontonCanada

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