Spontaneous Autoimmune Thyroiditis in the BUF Rat

  • N. R. Rose
  • P. E. Bigazzi
  • B. Noble
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73B)


The immune system has remarkable ability to distinguish self from non-self. Autoimmune diseases represent exceptions to the general rule of self-recognition. Their study provides clues about the basis of the rule. In most human autoimmune diseases of solid tissues, one sees infiltration by macrophages, plasma cells and eosinophils in addition to large numbers of lymphocytes. Autoimmune lesions may be the result of damage initiated by autoantibodies, by lymphocytes sensitized to self-antigen, by activated macrophages, or by the two or more of these factors combined.


Germinal Center Autoimmune Thyroiditis Thyroid Lesion Human Autoimmune Disease Chromic Chloride 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • N. R. Rose
    • 1
  • P. E. Bigazzi
    • 2
  • B. Noble
    • 2
  1. 1.Wayne State University School of MedicineDetroitUSA
  2. 2.School of MedicineState University of New York at BuffaloBuffaloUSA

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