Antigen and Immune Complex Induced Suppression of Delayed Hypersensitivity

  • E. R. Heise
  • E. Rowland
  • N. Beatty
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73B)


Both cellular and humoral immune responses are known to be regulated by mechanisms that are incompletely understood, especially with respect to delayed hypersensitivity (DH). Injection of soluble or alum-precipitated antigen near the time of sensitization prevents the development of DH and the synthesis of the gamma-2 class of antibody, leaving the gamma-1 class unaffected (1,3). Moreover, established DH is suppressed by systemic administration of specific antigen (6). Antigen-induced suppression of the induction and expression of DH has been termed “immune deviation” and “desensitization”, respectively. These experimental phenomena are thought to have counterparts in certain granulomatous diseases in which skin-test anergy is a prominent feature.


Bovine Serum Albumin Purify Protein Derivative Immune Deviation Free Bovine Serum Albumin Delay Hypersensitivity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Asherson, G.L. and Stone, S.H., Immunology, 9 (1965) 205.PubMedGoogle Scholar
  2. 2.
    Axelrad, M.A., Immunology., 15 (1968) 159.PubMedGoogle Scholar
  3. 3.
    Dvorak, H.F., Billote, J.B., McCarthy, J.S. and Flax, M.J., J. Immunol., 24 (1965) 966.Google Scholar
  4. 4.
    Kantor, F.S., Hall, C.B. and Lipsmeyer, E., Second Inter. Convocation of Immunol., Buffalo, New York, 1970, Karger, Basel, Switzerland (1971) 213.Google Scholar
  5. 5.
    Polak, L., Clin. Exp. Immunol., 19 (1975) 543.PubMedGoogle Scholar
  6. 6.
    Uhr, J.W. and Pappenheimer, A.M., Jr., J. Exp. Med., 108 (1958) 891.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • E. R. Heise
    • 1
  • E. Rowland
    • 1
  • N. Beatty
    • 1
  1. 1.Bowman Gray School of MedicineWinston - SalemUSA

Personalised recommendations