Lymphocyte Subpopulations: Analysis of T-Cell Rosette Characters
An important step in the elucidation of the thymus-derived (T) lymphocyte system was the discovery of specific cell surface antigens. The most thoroughly studied of these are those in mice. There, it is recognized that the θ antigen, among others, is specific to T-cells. Further, individual subpopulations of T-cells carry different quantities of 8 antigen on their cell surfaces. This antigen is higher in immature thymus cells than in cells of peripheral lymphoid organs (2). The T-cells of guinea pigs can also be distinguished from the rest by their ability to form rosettes with rabbit red blood cells (RRBC) (4). This paper deals with the characteristics of RRBC rosettes in various lymphoid organs. It was found that the rosettes of thymus cells possessed more RRBC than those of lymph node and spleen cells. The modulation of this parameter by various factors was the subject of this investigation.
KeywordsSpleen Cell Mature Type Lymphocyte Subpopulation Thymus Cell Peripheral Lymphoid Organ
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