Advertisement

A Macrophage Cell Surface Antigen

  • J. D. Stinnett
  • P. S. Morahan
  • A. M. Kaplan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73)

Abstract

Although biochemical studies on macrophage membranes have been performed (21), there is no gross chemical basis to distinguish phagocytes from non-phagocytic cells. By using intact cells for functional study, instead of isolated membrane preparations for gross chemical comparisons, certain interesting aspects of phagocytic function have emerged. One has been the plethora of “receptors” found on the macrophage cell surface. Macrophages express receptors for the Fc portion of immunoglobulin and the third component of complement (4,17,19,26). Moreover, the chemoattractant properties of certain compounds for macrophages, including products of the complement pathway (C3 and C5 activation products), implies the presence of receptors for these molecules as well (2,3,42). Macrophages can also “acquire” antigen specific receptors from T-cells rendering them cytotoxic to cells bearing those antigens, i.e., “armed” macrophages (11). Other lymphocyte products including migration inhibitory factor (MIF) also seem to act on macrophages via cell-surface receptors (35). Finally, macrophages non-specifically activated by numerous synthetic and biologic agents can selectively kill tumor cells, while having little or no cytocidal activity against normal cells (14,15,20). This event, also, most probably requires a recognition at the cell surface. Receptors are also responsible for the binding and subsequent phagocytosis of foreign bodies by macrophages, the alteration of phagocytic function by soluble lymphocyte products and the regulation of the phagocytic state of macrophages by hormones.

Keywords

Migration Inhibitory Factor Peritoneal Macrophage Membrane Extract Peritoneal Exudate Cell Divinyl Ether 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Argyris, B.F. and Plotkin, D.H., J. Immunol., 103 (1970) 372.Google Scholar
  2. 2.
    Becker, E.L., J. Exp. Med., 135 (1972) 376.PubMedCrossRefGoogle Scholar
  3. 3.
    Becker, E.L., The Phagocytic Cell in Host Resistance (Ed. J.A. Bellanti and D.H. Dayton) Raven Press, New York (1975) 1.Google Scholar
  4. 4.
    Benacerraf, B., Fed. Proc., 27 (1968) 46.PubMedGoogle Scholar
  5. 5.
    Bennett, B., Am. J. Pathol., 48 (1966) 165.PubMedGoogle Scholar
  6. 6.
    Boyse, E.A., Hamura, K., Stockert, E., Iritani, C.A. and Muira, M., Transplantation, 11 (1971) 351.PubMedCrossRefGoogle Scholar
  7. 7.
    Boyse, E.A., Miyazawa, T., Aoki, T. and Old, L.J., Proc. Roy. Soc. Ser. B. Biol. Sci., 170 (1968) 175.CrossRefGoogle Scholar
  8. 8.
    Boyse, E.A., Old, L.H. and Chomoulinkov, I., Meth. Med. Res., 10 (1964) 39.PubMedGoogle Scholar
  9. 9.
    Cayeux, P., Panijel, P., Cluzan, R. and Levillain, R., Nature, 212 (1966) 688.CrossRefGoogle Scholar
  10. 10.
    Despont, J.P. and Cruchard, A., Nature, 223 (1969) 838.PubMedCrossRefGoogle Scholar
  11. 11.
    Evans, R., Grant, C.K., Cox, H., Steele, K. and Alexander, P., J. Exp. Med., 136 (1972) 1318.Google Scholar
  12. 12.
    Gallily, R., Clin, Exp. Immunol., 9 (1971) 381.Google Scholar
  13. 13.
    Haustein, D., J. Immunol. Meth., 7 (1975) 25.CrossRefGoogle Scholar
  14. 14.
    Hibbs, J.B., J. Nat. Cancer Inst., 53 (1974) 1487.Google Scholar
  15. 15.
    Hibbs, J.B., Lambert, L.H. and Remington, J.S., J. Infect. Dis., 124 (1971) 587.PubMedCrossRefGoogle Scholar
  16. 16.
    Hirsch, M.S., Gary, G.W. and Murphy, F.A., J. Immunol., 102 (1969) 656.PubMedGoogle Scholar
  17. 17.
    Huber, H. and Fudenberg, H.H., Ser-Haematol. III, 2 (1970) 160.Google Scholar
  18. 18.
    Hunter, W.M. and Greenwood, F.C., Nature, 194 (1962) 495.PubMedCrossRefGoogle Scholar
  19. 19.
    Jonas, W.E., Gurner, B.W., Nelson, D.S. and Coombs, R.R.A., Int. Arch. Allergy, 28 (1965) 86.CrossRefGoogle Scholar
  20. 20.
    Kaplan, A.M., Morahan, P.S. and Regelson, W., J. Nat. Cancer Inst., 52 (1974) 1919.Google Scholar
  21. 21.
    Karnovsky, M.L., Progress in Immunology II, Vol. 4 (Ed. L. Brent and J. Holborow) North-Holland Publishing Co., New York (1974) 83.Google Scholar
  22. 22.
    Koren, H.S., Handwerger, B.S. and Wunderlich, J.R., J. Immunol., 114 (1975) 894.PubMedGoogle Scholar
  23. 23.
    Leibovich, S.J. and Ross, R., Am. J. Pathol., 78 (1974) 71.Google Scholar
  24. 24.
    McKenzie, I.F.C. and Snell, G.D., J. Immunol., 114 (1975) 848.PubMedGoogle Scholar
  25. 25.
    Maizel, J.V., Fundamental Techniques in Virology, Academic Press, New York (1969) 334.Google Scholar
  26. 26.
    Mantovani, B., Rabinovitch, M. and Nussenzweig, V., J. Exp. Med., 135 (1972) 780.PubMedCrossRefGoogle Scholar
  27. 27.
    Nachman, R.L., Ferris, B. and Hirsch, J.G., J. Exp. Med., 133 (1971) 785.PubMedCrossRefGoogle Scholar
  28. 28.
    Old, L.J., Boyse, E.A. and Stockert, E.J., J. Nat. Cancer Inst., 31 (1963) 977.PubMedGoogle Scholar
  29. 29.
    Panijel, J. and Cayeux, P., Immunology, 14 (1968) 769.PubMedGoogle Scholar
  30. 30.
    Pearson, L.D. and Osebold, J.W., Infect. Immun., 7 (1973) 479. 11. Pearson, L.D. and Osebold, J.W., Infect. Immun., 9 (1974) 127.Google Scholar
  31. 32.
    Raff, M.C. and Cantor, H., Progress in Immunology (Ed. B. Amos) Academic Press, New York (1971) 83.Google Scholar
  32. 33.
    Raff, M.C., Nase, S. and Mitchison, N.A., Nature, 230 (1971) 50.PubMedCrossRefGoogle Scholar
  33. 34.
    Reif, A.E. and Allen, J.M.V., J. Exp. Med., 120 (1973) 413.CrossRefGoogle Scholar
  34. 35.
    Remold, H.G., J. Exp. Med., 138 (1973) 1065.Google Scholar
  35. 36.
    Schwartz, B.D. and Nathenson, S.G., J. Immunol., 107 (1962) 495.Google Scholar
  36. 37.
    Shigeno, N., Hammerling, U., Arpels, C., Boyse, E.A. and Old, L.J., Lancet, 2 (1968) 320.PubMedCrossRefGoogle Scholar
  37. 38.
    Takahashi, T., Old, L.J., Hsu, C.J. and Boyse, E.A., Eur. J. Immunol., 1 (1971) 487.CrossRefGoogle Scholar
  38. 39.
    Tiller, G.E., McGiven, A.R. and Phil, E., Aust. J. Exp. Biol. Med. Sci., 51 (1973) 793.CrossRefGoogle Scholar
  39. 40.
    Unanue, E.R., Nature, 218 (1968) 36.PubMedCrossRefGoogle Scholar
  40. 41.
    Vitetta, E.S. and Uhr, J.W., Transplant. Rev., 14 (1973) 50.PubMedGoogle Scholar
  41. 42.
    Ward, P.A., Am. J. Pathol., 77 (1974) 520.PubMedGoogle Scholar
  42. 43.
    Zisman, B., Hirsch, M.S. and Allison, A.C., J. Immunol., 104 (1970) 1155.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • J. D. Stinnett
    • 1
  • P. S. Morahan
    • 1
  • A. M. Kaplan
    • 1
  1. 1.MCV/VCU Cancer CenterMedical College of VirginiaRichmondUSA

Personalised recommendations