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Cellular Basis for the Generation of B-Cell Diversity

  • M. D. Cooper
  • C. E. Grossi
  • P. M. Lydyard
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73)

Abstract

Birds, especially domestic strains of chicken, have provided pivotal models for the study of certain aspects of the organization of the immune system in higher vertebrates. Many of the principles of the graft-versus-host phenomenon and the surprisingly high frequency of lymphocytes reactive to histocompatibility antigens were elucidated originally in chickens (41). At about the same time, the avian bursa of Fabricius was found to control development of antibody responsiveness (13). Later the bursa was shown to be essential for the development of avian lymphoid leukosis (35). These findings, and the discoveries in mammals of the central roles played by the thymus in lymphomagenesis and in normal development of immunocompetent cells, paved the way for elucidation of the separate pathways followed by thymus (T) and bursal or bursa-equivalent (B) lines of lymphoid cells during normal and neoplastic development (8,9,47). Studies in the chick also provided a firm embryologic basis for the concept of a mesenchymal origin of hemopoietic stem cells for both T and B and other blood cell lines (31).

Keywords

Lymphoid Follicle Hemopoietic Stem Cell Antibody Diversity Peripheral Lymphoid Tissue Blood Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • M. D. Cooper
    • 1
  • C. E. Grossi
    • 2
  • P. M. Lydyard
    • 1
  1. 1.University of AlabamaBirminghamUSA
  2. 2.Department of AnatomyUniversity of GenovaItaly

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