Advertisement

Potentiated Lysosomal Enzyme, Bacteriostatic and Bactericidal Activities of Peritoneal Macrophages of Mice Treated With the MER Fraction of Tubercle Bacilli

  • R. Gallily
  • S. Yagel
  • D. W. Weiss
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73)

Abstract

The MER fraction of tubercle bacilli is a potent nonspecific modulator of immunological responsiveness, and capable of heightening the resistance of experimental animals and patients to neoplastic cells and microbial pathogens (3,8,9,10,11,12). As macrophages play a central role in immunological and defense reactions, it was of interest to study the effects of MER on various functions of these cells. The present communication reports the results of initial investigations on the effect of MER on the enzymatic, phagocytic, bacteriostatic and bactericidal activities of mouse peritoneal macrophages.

Keywords

Acid Phosphatase Peritoneal Macrophage Lysosomal Enzyme C57Bl Mouse Mouse Peritoneal Macrophage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Barrett, A.I., Biochem. J., 104 (1967) 601.PubMedGoogle Scholar
  2. 2.
    Beck, C., Mahadevan, S., Brightwell, R., Dillard, C.J. and Tappel, A.L., Arch. Biochem, Biophys., 128 (1968) 369.CrossRefGoogle Scholar
  3. 3.
    Cuttner, J., Holland, J.F., Bekesi, J.G., Ramachandar, K. and Donovan, P., Proc. Amer. Soc. Clin. Oncol., 16 (1975) 264.Google Scholar
  4. 4.
    Gallily, R., Cellular Immunol., 15 (1975) 419.CrossRefGoogle Scholar
  5. 5.
    Gallily, R. and Eliahu, H., Immunology, 26 (1974) 603.PubMedGoogle Scholar
  6. 6.
    Geiger, B. and Gallily, R., Clin. Exp. Immunol., 16 (1974) 643.PubMedGoogle Scholar
  7. 7.
    Lahav, M., Neeman, N., Adler, E. and Ginsburg, I., J. Infect. Dis., 129 (1974) 528.PubMedCrossRefGoogle Scholar
  8. 8.
    Moertel, C.G., Ritts, R.E., Schutt, A.J. and Hahn, R.G., Proc. Amer. Assoc. Cancer Res., 16 (1975) 143.Google Scholar
  9. 9.
    Richman, S.P., Proc. Amer. Soc. Clin. Oncol., 16 (1975) 227.Google Scholar
  10. 10.
    Weiss, D.W., Nat. Cancer Inst. Monogr., 35 (1972) 157.Google Scholar
  11. 11.
    Weiss, D.W., Medical Clinics Symposium on Immunotherapy in Malignant Disease (Ed. W. D. Terry) W.B. Saunders Co., Philadelphia, Pennsylvania (1976) in press.Google Scholar
  12. 12.
    Weiss, D.W. and Yashphe, D.J.. I (Ed. A. Zuckerman and D.W. Weiss) Academic Press, New York, New York (1973) 163.Google Scholar
  13. 13.
    Yagel, S., Gallily, R. and Weiss, D.W., Cell. Immunol., 19 (1975) 381.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • R. Gallily
    • 1
  • S. Yagel
    • 1
  • D. W. Weiss
    • 1
  1. 1.The Hebrew University-Hadassah Medical SchoolJerusalemIsrael

Personalised recommendations