Advertisement

Complement Independent Lipopolysaccharide (LPS) Induced Hypotension and Disseminated Intravascular Coagulation: a Correlation of LPS Structure with in Vivo and in Vitro Biological Activities

  • R. J. Ulevitch
  • D. C. Morrison
  • C. G. Cochrane
  • P. M. Henson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73)

Abstract

Gram-negative bacteremía is a serious clinical problem with an estimated 30–50% mortality rate in adult patients (17). It has been proposed that lipopolysaccharide (LPS), a constituent of the cell wall of virtually all gram-negative bacteria may be responsible for initiating the multiple pathophysiologic changes occurring in patients with gram-negative sepsis. LPS has been the subject of intensive study during this century (33) and the chemical structures of preparations isolated from a variety of gram-negative bacteria have been elucidated.

Keywords

Peripheral Blood Cell Serum Complement Mediation System Anticomplementary Activity Scripps Clinic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Beller, F.K., Thrombosis et Diathesis Haemmorrhagia Suppl., 36 (1969) 125.Google Scholar
  2. 2.
    Brown, D.L., Progress in Immunology II. Vol. I. (Ed. L. Brent and J. Holbrow) North-Holland Publishing Co. (1974) 191.Google Scholar
  3. 3.
    Brown, D.L. and Lachmann, P.J., Int. Arch. Allergy, 75 (1972) 193.Google Scholar
  4. 4.
    Chiller, J.M., Skidmore, B.J., Morrison, D.C. and Weigle, W.O., Pzoc. Nat. Acad. Sci., 70 (1973) 2129.CrossRefGoogle Scholar
  5. 5.
    Cochrane, C.G., Aidkin, B.S. and Muller-Eberhard, H.J., J. Immunol., 105 (1970) 55.PubMedGoogle Scholar
  6. 6.
    Evensen, S.A. and Shepro, D., Micravascular Res., 8 (1974) 90.CrossRefGoogle Scholar
  7. 7.
    Fine, D.P., J. Immunol., 112 (1974) 763.PubMedGoogle Scholar
  8. 8.
    From, A.H.L., Gewurz, H., Gruninger, R.P., Pickering, R.J. and Spink, W.W., Infect. Immun., 2 (1970) 38.PubMedGoogle Scholar
  9. 9.
    Galanos, C., Rietschel, E. T., Luderitz, O. and Westphal, O., Europ. J. Biochem., 19 (1971) 143.PubMedCrossRefGoogle Scholar
  10. 10.
    Garner, R., Chater, B.V. and Brown, D.L., Brit. J. Haematol., 28 (1974) 398.CrossRefGoogle Scholar
  11. 11.
    Gilbert, R.P., Physiol. Rev., 40 (1960) 245.PubMedGoogle Scholar
  12. 12.
    Gilbert, V.E. and Braude, A.I., J. Exp. Med., 116 (1962) 477.PubMedCrossRefGoogle Scholar
  13. 13.
    Guenter, C.A., Fiorica, V. and Hinshaw, L.B., J. Appl. Phys., 26 (1969) 780.Google Scholar
  14. 14.
    Henson, P.M. and Cochrane, C.G., J. Exp. Med., 129 (1969) 167.PubMedCrossRefGoogle Scholar
  15. 15.
    Kitzmiller, J.L., Lucas, W.E. and Yelenosky, P.F., Am. J. Obstet. Gynecol., 112 (1972) 414.PubMedGoogle Scholar
  16. 16.
    Lachmann, P.J. and Nicol, P.A.E., Advances in the Biosciences (Ed. G. Raspe and S. Bernhard) Pergamon Press,Vieweg (1974) 6.Google Scholar
  17. 17.
    McCabe, W.R., Adv. Int. Med., 19 (1974) 135.Google Scholar
  18. 18.
    McCall, C.E., DeCatlet, C.R., Brown, D. and Lachmann, P., Nature, 249 (1974) 841.PubMedCrossRefGoogle Scholar
  19. 19.
    McGrath, J.M. and Stewart, G.J., J. Exp. Med., 129 (1969) 833.PubMedCrossRefGoogle Scholar
  20. 20.
    McKay, D.G., Endotoxin, 29 (1973) 11.Google Scholar
  21. 21.
    Mancini, G.A., Carbonar, A.O. and Heremans, J.F., Immunochemistry, 2 (1965) 235.PubMedCrossRefGoogle Scholar
  22. 22.
    Melmon, K.C. and Cline, M.J., Biochem. Pharm. Suppl., 17 (1968) 271.CrossRefGoogle Scholar
  23. 23.
    Mergenhagen, S.E., Gweurz, H., Bladen, H.A., Nawatny, A., Kasai, N. and Luderitz, O., J. Immunol., 100 (1968) 227.PubMedGoogle Scholar
  24. 24.
    Mergenhagen, S.E., Snyderman, R., Gewurz, H. and Shin, H.S., Curr. Topics Micro. Immunol., 50 (1969) 37.CrossRefGoogle Scholar
  25. 25.
    Morrison, D.C., Cochrane, C.G., J. Exp. Med., 140 (1974) 797.PubMedCrossRefGoogle Scholar
  26. 26.
    Morrison, D.C. and Leire, L., J. Biol. Chem., 250 (1975) 2911.PubMedGoogle Scholar
  27. 27.
    Morrison, D.C. and Verroust, P., Proc. Soc. Exp. Biol. Med., 142 (1973) 1025.Google Scholar
  28. 28.
    Muller-Berhaus, G. and Lahmann, E., Brit. J. Haematol., 28 (1974) 403.CrossRefGoogle Scholar
  29. 29.
    Phillips, J.K., Snyderman, R. and Mergenhagen, S.E., J. Immunol., 109 (1972) 334.PubMedGoogle Scholar
  30. 30.
    Rietschel, E. T., Gottert, H., Luderitz, O. and Westphal, O., Europ. J. Biochem., 28 (1972) 166.Google Scholar
  31. 31.
    Snyderman, R. and Pike, M.C., Infect. Immun., 11 (1975) 273.PubMedGoogle Scholar
  32. 32.
    Stewart, G.J. and Anderson, M.J., Brit. J. Exp. Path., 52 (1971) 75PubMedGoogle Scholar
  33. 33.
    Westphal, 0., Int. Arch. Allergy, 49 (1975) 1.CrossRefGoogle Scholar
  34. 34.
    Westphal, 0., Gmeiner, J., Ludertz, 0., Tanaka, A. and Eichen-berger, E., Colloq. Int. Centre Nat. Rech. Sci., 174 (1969) 69Google Scholar
  35. 35.
    Zimmerman, T.S., Arroyave, C.M., Muller-Eberhard, H.J., J. Exp. Med., 134 (1971) 1591.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • R. J. Ulevitch
    • 1
  • D. C. Morrison
    • 1
  • C. G. Cochrane
    • 1
  • P. M. Henson
    • 1
  1. 1.Scripps Clinic and Research FoundationLa JollaUSA

Personalised recommendations