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Mechanisms of Lymphocyte Activation: Effect of Ligand Concentration and Induction Time

  • G. B. Faguet
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73)

Abstract

Although the study of the interactions of phytohemagglutinin (PHA) with specific lymphocyte membrane receptors by us (Faguet, unpublished observations) and other investigators (1,17,20,34) has shed light on these surface phenomena the transduction mechanisms responsible for the biochemical and metabolic activation of PHA-responsive cells remains largely unsolved. When stimulated by a wide spectrum of PHA concentrations, normal lymphocytes exhibit a minimal activating PHA concentration threshold and demonstrate a characteristic pattern of response (12). The relevance and clinical usefulness of these findings derive from the detection and quantitation of lymphocyte abnormalities in most patients with some neoplastic diseases and non-malignant processes, such as Hodgkin’s disease (13) and sarcoidosis (Faguet, unpublished observations), respectively. However, it is uncertain whether this concentration-dependent response reflects graded responses by all cells, or whether it represents increasing percentages of cells responding in an all or none fashion (22).

Keywords

Induction Time Lymphocyte Activation Lymphocyte Membrane Lymphocyte Abnormality Leucocyte Cult 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • G. B. Faguet
    • 1
  1. 1.Medical College of GeorgiaAugustaUSA

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