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The Selection and Design of Lysosomotropic Drugs

  • P. J. Jacques
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73)

Abstract

Lysosomotropic drugs are exogenous pharmacologically active materials which, after administration to the organism, are found concentrated within one or another type of vacuole composing the exoplasmic apparatus, e.g., hetero- or autophagosomes, primary or secondary lysosomes, postlysosomes (Fig. 1). Their usage, in view of the preventive or curative therapy of highly diversified cellular disorders, materializes the prophetic vision formulated as early as 1890 by Paul Ehrlich, the father of modern chemotherapy: “...cellular therapy is a consequence of specific cell nutrition, as the cell can really be influenced, only by those agents which, for what the expression is worth, are eaten by it.”

Keywords

Enzyme Replacement Therapy Chronic Granulomatous Disease Lysosomal Storage Disease Secondary Lysosome Cytoplasmic Matrix 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • P. J. Jacques
    • 1
  1. 1.Institut Pasteur du BrabantUniversité Catholique de Louvain en WoluweBrusselsBelgium

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